Evaluating the clinical value of oscillatory cardiopulmonary coupling in   patients with obstructive sleep apnea hypopnea syndrome by impedance   cardiogram

doi:10.1016/j.sleep.2015.09.025

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	Evaluating the clinical value of oscillatory cardiopulmonary coupling in patients with obstructive sleep apnea hypopnea syndrome by impedance cardiogram
	Chen, Xue ; Zhou, Ting ; Li, Dongfang ; Zhang, Cheng ; Jia, Peng ; Ma, Jing ; Zhang, Jue ; Wang, Guangfa ; Fang, Jing
刊名	SLEEP MEDICINE
	2016
关键词	Impedance cardiogram Obstructive sleep apnea hypopnea syndrome Empirical mode decomposition Detrended fluctuation decomposition Oscillatory cardiopulmonary coupling EMPIRICAL MODE DECOMPOSITION SELF-ORGANIZED CRITICALITY HEART-RATE-VARIABILITY CARDIAC-OUTPUT MYOCARDIAL-INFARCTION ATRIAL-FIBRILLATION CIRCADIAN VARIATION STROKE VOLUME TIME-SERIES FAILURE
DOI	10.1016/j.sleep.2015.09.025
英文摘要	Objectives: For patients with obstructive sleep apnea hypopnea syndrome (OSAHS), chronic inflammation and hemodynamic oscillations caused by respiratory events contribute to cardiovascular disease (CVD). In this study, a physiological marker named oscillatory coupling factor (OCF) exacted from cardiac output (CO) was introduced. This study aimed to evaluate the clinical value of OCF and tentatively explore its predictive value of cardiovascular prognosis in OSAHS patients. Methods: An impedance cardiogram (ICG) was used to continuously obtain the participants' CO with simultaneous polysomnography. Participants were divided into three groups: an OSAHS-CVD-group (n = 19); an OSAHS + CVD- group (n = 34); and an OSAHS + CVD + group (n = 36). The OCF was exacted from the CO by using empirical mode decompensation-based detrended fluctuation analysis (EMD-DFA). Results: The OCF values were: OSAHS + CVD + group [1.20 (0.98-1.78)] > OSAHS + CVD-group [1.14 (1.02-1.94)] > OSAHS-CVD-group [0.95 (0.56-1.16)], (p = 0.001). A Spearman test showed that OCF was positively correlated with age, apnea/hypopnea index (AHI), microarousal index (MAI), oxygen desaturation index (ODI), and negatively correlated with the lowest SpO(2). Ten participants were treated by one-night continuous positive airway pressure (CPAP): their AHI decreased from 44.9 (18.0-72.9)/hour to 1.25 (0.07.5)/hour, and their OCF fell from 1.17 (1.10-1.69) to 1.08 (0.96-1.23) (p = 0.038). Seventy-seven participants were effectively followed up. Seven participants developed CVD events or newly diagnosed CVD; their OCFs were distributed on a relatively high level [1.18 (1.01-1.56)]. Conclusion: The OSAHS participants had higher OCFs than those without OSAHS, while CVD made the OCFs even higher; CPAP could rectify this change. Oscillatory coupling factor may be a physiological marker of cardiopulmonary coupling and have potential cardiovascular prognostic value for people with OSAHS. (C) 2015 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China [81341005]; SCI(E); PubMed; ARTICLE; majjmail@163.com; zhangjue@pku.edu.cn; 75-84; 19
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433662]
专题	工学院
推荐引用方式 GB/T 7714	Chen, Xue,Zhou, Ting,Li, Dongfang,et al. Evaluating the clinical value of oscillatory cardiopulmonary coupling in patients with obstructive sleep apnea hypopnea syndrome by impedance cardiogram[J]. SLEEP MEDICINE,2016.
APA	Chen, Xue.,Zhou, Ting.,Li, Dongfang.,Zhang, Cheng.,Jia, Peng.,...&Fang, Jing.(2016).Evaluating the clinical value of oscillatory cardiopulmonary coupling in patients with obstructive sleep apnea hypopnea syndrome by impedance cardiogram.SLEEP MEDICINE.
MLA	Chen, Xue,et al."Evaluating the clinical value of oscillatory cardiopulmonary coupling in patients with obstructive sleep apnea hypopnea syndrome by impedance cardiogram".SLEEP MEDICINE (2016).