Altered Resting-State Brain Activity and Connectivity in Depressed   Parkinson&apos;s Disease

doi:10.1371/journal.pone.0131133

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	Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson's Disease
	Hu, Xiao ; Song, Xiaopeng ; Li, Erfeng ; Liu, Jiajia ; Yuan, Yonggui ; Liu, Weiguo ; Liu, Yijun
刊名	PLOS ONE
	2015
关键词	NONMOTOR SYMPTOMS DISORDER ACTIVATION NETWORKS CORTEX
DOI	10.1371/journal.pone.0131133
英文摘要	Depressive symptoms are common in Parkinson's disease (PD), but the neurophysiological mechanisms of depression in PD are poorly understood. The current study attempted to examine disrupted spontaneous local brain activities and functional connectivities that underlie the depression in PD. We recruited a total of 20 depressed PD patients (DPD), 40 non-depressed PD patients (NDPD) and 43 matched healthy controls (HC). All the subjects underwent neuropsychological tests and resting-state fMRI scanning. The between-group differences in the amplitude of low frequency fluctuations (ALFF) of BOLD signals were examined using post-hoc tests after the analysis of covariance. Compared with the NDPD and HC, the DPD group showed significantly increased ALFF in the left median cingulated cortex (MCC). The functional connectivity (FC) between left MCC and all the other voxels in the brain were then calculated. Compared with the HC and NDPD group, the DPD patients showed stronger FC between the left MCC and some of the major nodes of the default mode network (DMN), including the post cingulated cortex/precuneus, medial prefrontal cortex, inferior frontal gyrus, and cerebellum. Correlation analysis revealed that both the ALFF values in the left MCC and the FC between the left MCC and the nodes of DMN were significantly correlated with the Hamilton Depression Rating Scale score. Moreover, higher local activities in the left MCC were associated with increased functional connections between the MCC and the nodes of DMN in PD. These abnormal activities and connectivities of the limbic-cortical circuit may indicate impaired high-order cortical control or uncontrol of negative mood in DPD, which suggested a possible neural mechanism of the depression in PD.; National Natural Science Foundation of China [61131003]; SCI(E); PubMed; ARTICLE; wgliunbh@sina.com; yijunliu@ufl.edu; 7; e0131133; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418560]
专题	工学院
推荐引用方式 GB/T 7714	Hu, Xiao,Song, Xiaopeng,Li, Erfeng,et al. Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson's Disease[J]. PLOS ONE,2015.
APA	Hu, Xiao.,Song, Xiaopeng.,Li, Erfeng.,Liu, Jiajia.,Yuan, Yonggui.,...&Liu, Yijun.(2015).Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson's Disease.PLOS ONE.
MLA	Hu, Xiao,et al."Altered Resting-State Brain Activity and Connectivity in Depressed Parkinson's Disease".PLOS ONE (2015).