A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with   immobilized silver nanoparticles

doi:10.1016/j.matlet.2015.05.084

CORC > 北京大学 > 工学院

	A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles
	Jia, Zhaojun ; Li, Ming ; Xiu, Peng ; Xu, Xuchen ; Cheng, Yan ; Zheng, Yufeng ; Xi, Tingfei ; Wei, Shicheng ; Liu, Zhongjun
刊名	MATERIALS LETTERS
	2015
关键词	Electron beam melting (EBM) Micro-arc oxidization (MAO) Poly(dopamine) (PD) Silver nanoparticles (AgNPs) MICRO-ARC OXIDATION IMPLANTS STRESS
DOI	10.1016/j.matlet.2015.05.084
英文摘要	Owing to their mechanical properties and bioinertness titanium alloys remain the preferred load-bearing implant material in orthopedics. However, unsatisfactory osteointegration and risks of infection are the two major problems. Herein, Ti6Al4V prostheses with 3D hierarchical (macro/micro-nano) porosity were constructed by combining the state-of-art electron beam melting (EBM) additive manufacturing (AM) process with a traditional micro-arc oxidization (MAO) technique for enhanced integration with bone tissues, and as a measure to improve their antimicrobial properties, releasable silver nanoparticles (AgNPs) were homogeneously immobilized on the multi-scaled porous surfaces via a mussel-inspired strategy. The cytocompatibility of the engineered scaffolds (EBM-MAO/Ag) outperformed the untreated, due to synergistic benefits from micro/nano-porous topography and adhesive chemical composition. (C) 2015 Elsevier B.V. All rights reserved.; Grants of the Project of Scientific and Technical Plan of Beijing [Z141100002814008]; National Natural Science Foundation of China [31370954]; State Key Laboratory of Bioelectronics Open Research Fund of China (Chien-Shiung Wu Laboratory); National Basic Research Program (973) of China [2012CB619102]; SCI(E); EI; ARTICLE; chengyan@pku.edu.cn; 143-146; 157
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/415748]
专题	工学院
推荐引用方式 GB/T 7714	Jia, Zhaojun,Li, Ming,Xiu, Peng,et al. A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles[J]. MATERIALS LETTERS,2015.
APA	Jia, Zhaojun.,Li, Ming.,Xiu, Peng.,Xu, Xuchen.,Cheng, Yan.,...&Liu, Zhongjun.(2015).A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles.MATERIALS LETTERS.
MLA	Jia, Zhaojun,et al."A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles".MATERIALS LETTERS (2015).