Double-medium pharmacokinetic analysis of two-step approaches in spheric and oblate spheric tumor using bifunctional antibodies and enzyme-conjugated for cancer diagnosis and therapy

CORC > 北京大学 > 工学院

	Double-medium pharmacokinetic analysis of two-step approaches in spheric and oblate spheric tumor using bifunctional antibodies and enzyme-conjugated for cancer diagnosis and therapy
	Yangqing, X. ; Gongbi, W.
刊名	中国生物医学工程学报英文版
	1998
英文摘要	Physiological barrier existing in malignant tumor prevented medicine molecule to reach the inner core of tumor, thereby it was difficult to diagnose and treat the tumor. Two-step approaches using low molecular weight agents with high specificity surmounted this difficulty to some extent, and a detailed pharmacokinetic analysis of two-step approaches in spheric and oblate spheric tumors using bi-functional antibodies and enzymeconjugated ones with blood-tissue double-medium model is provided. The effect of the way, dose and time schedule of injection, and the sensibility of the distribution of medicine to the dynamical and reactive coefficients, are analysed. Then the BFA system is compared with the ECA system, as well as the distribution of pressure and medicine in oblate spheric tumor; and finally, based on these results, some clinical suggestions on tumor diagnosis and therapy were given.; EI; 0; 3; 199-207; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/409275]
专题	工学院
推荐引用方式 GB/T 7714	Yangqing, X.,Gongbi, W.. Double-medium pharmacokinetic analysis of two-step approaches in spheric and oblate spheric tumor using bifunctional antibodies and enzyme-conjugated for cancer diagnosis and therapy[J]. 中国生物医学工程学报英文版,1998.
APA	Yangqing, X.,&Gongbi, W..(1998).Double-medium pharmacokinetic analysis of two-step approaches in spheric and oblate spheric tumor using bifunctional antibodies and enzyme-conjugated for cancer diagnosis and therapy.中国生物医学工程学报英文版.
MLA	Yangqing, X.,et al."Double-medium pharmacokinetic analysis of two-step approaches in spheric and oblate spheric tumor using bifunctional antibodies and enzyme-conjugated for cancer diagnosis and therapy".中国生物医学工程学报英文版 (1998).