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	Evaluation of Extracellular Matrix-Based Nerve Conduits for Long-Gap Peripheral Nerve Repair in a Goat Model
	Zhang, Wei ; Xu, Bin ; Zhang, Ying ; Luo, Ying
	2014
关键词	Extracellular Matrix Nerve Conduit Peripheral Nerve Peroneal Nerve SCIATIC-NERVE COLLAGEN CONDUITS GROWTH-FACTOR STEM-CELLS IN-VITRO REGENERATION GRAFT RECONSTRUCTION SCAFFOLD DEFECTS
DOI	10.1166/jbt.2014.1252
英文摘要	Peripheral nerve injury is a common traumatic illness in clinic, and long-gap injury in particular has been difficult to repair. In this study, a new type of biological nerve conduits with tunable diameters and lengths were fabricated from extracellular matrices (ECM) derived from porcine small intestinal submucosa. A peroneal nerve defect model was established by removing the left common peroneal nerve of pre-defined lengths in goats. The biological conduits were sutured in and their functions to repair 2 cm, 4 cm, 6 cm and 8 cm nerve defects were investigated for a 12 month period. Electrophysiological, histological, and TEM examinations showed normal nerve conductive velocities and regeneration of myelinated nerve fibers in 2 cm and 4 cm defects grafted with ECM-based conduits. The effects of these biological conduits on the repair of 2 cm and 4 cm nerve defects were comparable to those of allograft nerves. The repair function of nerve conduits was found to decrease with the defect lengths. The ECM-based nerve conduits may possess advantageous bioactive properties to support nerve tissue regeneration and have potential for future clinical use in long-gap nerve injury repair.; Cell & Tissue Engineering; SCI(E); 0; ARTICLE; 12,SI; 1063-1072; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/387746]
专题	工学院
推荐引用方式 GB/T 7714	Zhang, Wei,Xu, Bin,Zhang, Ying,et al. Evaluation of Extracellular Matrix-Based Nerve Conduits for Long-Gap Peripheral Nerve Repair in a Goat Model[J],2014.
APA	Zhang, Wei,Xu, Bin,Zhang, Ying,&Luo, Ying.(2014).Evaluation of Extracellular Matrix-Based Nerve Conduits for Long-Gap Peripheral Nerve Repair in a Goat Model..
MLA	Zhang, Wei,et al."Evaluation of Extracellular Matrix-Based Nerve Conduits for Long-Gap Peripheral Nerve Repair in a Goat Model".(2014).

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