Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks   in Cardiac Myocytes

doi:10.1371/journal.pone.0057093

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	Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes
	Chen, Xi ; Kang, Jianhong ; Fu, Ceji ; Tan, Wenchang
刊名	plos one
	2013
关键词	HEART-MUSCLE CA2+ SPARKS ACTIVATION CURRENTS RELEASE
DOI	10.1371/journal.pone.0057093
英文摘要	Ca2+ sparks and Ca2+ waves play important roles in calcium release and calcium propagation during the excitation-contraction (EC) coupling process in cardiac myocytes. Although the classical Fick's law is widely used to model Ca2+ sparks and Ca2+ waves in cardiac myocytes, it fails to reasonably explain the full-width at half maximum(FWHM) paradox. However, the anomalous subdiffusion model successfully reproduces Ca2+ sparks of experimental results. In this paper, in the light of anomalous subdiffusion of Ca2+ sparks, we develop a mathematical model of calcium wave in cardiac myocytes by using stochastic Ca2+ release of Ca2+ release units (CRUs). Our model successfully reproduces calcium waves with physiological parameters. The results reveal how Ca2+ concentration waves propagate from an initial firing of one CRU at a corner or in the middle of considered region, answer how large in magnitude of an anomalous Ca2+ spark can induce a Ca2+ wave. With physiological Ca2+ currents (2pA) through CRUs, it is shown that an initial firing of four adjacent CRUs can form a Ca2+ wave. Furthermore, the phenomenon of calcium waves collision is also investigated.; Multidisciplinary Sciences; SCI(E); PubMed; 2; ARTICLE; 3; e57093; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342928]
专题	工学院
推荐引用方式 GB/T 7714	Chen, Xi,Kang, Jianhong,Fu, Ceji,et al. Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes[J]. plos one,2013.
APA	Chen, Xi,Kang, Jianhong,Fu, Ceji,&Tan, Wenchang.(2013).Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes.plos one.
MLA	Chen, Xi,et al."Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes".plos one (2013).