Hemodynamic analysis of patient-specific coronary artery tree

doi:10.1002/cnm.2708

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	Hemodynamic analysis of patient-specific coronary artery tree
	Zhang, Jun-Mei ; Luo, Tong ; Tan, Swee Yaw ; Lomarda, Aileen Mae ; Wong, Aaron Sung Lung ; Keng, Felix Yung Jih ; Allen, John Carson ; Huo, Yunlong ; Su, Boyang ; Zhao, Xiaodan ; Wan, Min ; Kassab, Ghassan S. ; Tan, Ru San ; Zhong, Liang
刊名	international journal for numerical methods in biomedical engineering
	2015
DOI	10.1002/cnm.2708
英文摘要	Local hemodynamic parameters, such as wall shear stress (WSS), oscillatory shear index and relative resident time (RRT), have been linked to coronary plaque initiation and progression. In this study, a left coronary artery tree model was reconstructed from computed tomography angiography images of a patient with multiple stenoses. The geometry of the coronary artery tree model was virtually restored by eliminating the lesions, essentially re-creating the virtually healthy artery anatomy. Using numerical simulations, flow characteristics and hemodynamic parameter distributions in the stenosed and virtually healthy models were investigated. In the virtually healthy artery model, disturbed flows were found at four locations, prone to initialization of plaque formation. Low WSS and high RRT were exhibited in three of the four locations, and high WSS and low RRT were exhibited in the fourth. These findings suggest that coronary plaque is more likely to form in locations with disturbed flow conditions characterized by low WSS and high RRT or high WSS and low RRT. In addition, clinical index of fractional flow reserve was found to significantly correlate with blood flow rate, rather than anatomic parameters, such as diameter stenosis, which implied the importance of hemodynamic environment in stenosis formation. ? 2015 John Wiley & Sons, Ltd.; SCI(E); EI; 0; ARTICLE; zhong.liang@nhcs.com.sg; 4; e02708; 31
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/329126]
专题	工学院
推荐引用方式 GB/T 7714	Zhang, Jun-Mei,Luo, Tong,Tan, Swee Yaw,et al. Hemodynamic analysis of patient-specific coronary artery tree[J]. international journal for numerical methods in biomedical engineering,2015.
APA	Zhang, Jun-Mei.,Luo, Tong.,Tan, Swee Yaw.,Lomarda, Aileen Mae.,Wong, Aaron Sung Lung.,...&Zhong, Liang.(2015).Hemodynamic analysis of patient-specific coronary artery tree.international journal for numerical methods in biomedical engineering.
MLA	Zhang, Jun-Mei,et al."Hemodynamic analysis of patient-specific coronary artery tree".international journal for numerical methods in biomedical engineering (2015).