Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell   Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal   Imaging

doi:10.1002/adfm.201200133

CORC > 北京大学 > 工学院

	Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging
	Wang, Chao ; Ma, Xinxing ; Ye, Shuoqi ; Cheng, Liang ; Yang, Kai ; Guo, Liang ; Li, Changhui ; Li, Yonggang ; Liu, Zhuang
刊名	先进功能材料
	2012
关键词	single-walled carbon nanotubes protamine mesenchymal stem cells stem cell tracking multimodal imaging MAGNETIC-RESONANCE BONE-MARROW MYOCARDIAL-INFARCTION DRUG-DELIVERY LIVING MICE RAMAN-SPECTROSCOPY QUANTUM DOTS DIFFERENTIATION TRACKING THERAPY
DOI	10.1002/adfm.201200133
英文摘要	Stem cells have shown great potential in regenerative medicine and attracted tremendous interests in recent years. Sensitive and reliable methods for stem cell labeling and in vivo tracking are thus urgently needed. Here, a novel approach to label human mesenchymal stem cells (hMSCs) with single-walled carbon nanotubes (SWNTs) for in vivo tracking by triple-modal imaging is presented. It is shown that polyethylene glycol (PEG) functionalized SWNTs conjugated with protamine (SWNT-PEG-PRO) exhibit extremely efficient cell entry into hMSCs, without affecting their proliferation and differentiation. The strong inherent resonance Raman scattering of SWNTs is used for in vitro and in vivo Raman imaging of SWNT-PEG-PRO-labeled hMSCs, enabling ultrasensitive in vivo detection of as few as 500 stem cells administrated into mice. On the other hand, the metallic catalyst nanoparticles attached on nanotubes can be utilized as the T2-contrast agent in magnetic resonance (MR) imaging of SWNT-labeled hMSCs. Moreover, in vivo photoacoustic imaging of hMSCs in mice is also demonstrated. The work reveals that SWNTs with appropriate surface functionalization have the potential to serve as multifunctional nanoprobes for stem cell labeling and multi-modal in vivo tracking.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000304749600017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter; SCI(E); EI; 41; ARTICLE; 11; 2363-2375; 22
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/233348]
专题	工学院
推荐引用方式 GB/T 7714	Wang, Chao,Ma, Xinxing,Ye, Shuoqi,et al. Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging[J]. 先进功能材料,2012.
APA	Wang, Chao.,Ma, Xinxing.,Ye, Shuoqi.,Cheng, Liang.,Yang, Kai.,...&Liu, Zhuang.(2012).Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging.先进功能材料.
MLA	Wang, Chao,et al."Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and In Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging".先进功能材料 (2012).