In vivo stimulation of bone formation by aluminum and oxygen plasma   surface-modified magnesium implants

doi:10.1016/j.biomaterials.2013.08.052

CORC > 北京大学 > 工学院

	In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants
	Wong, Hoi Man ; Zhao, Ying ; Tam, Vivian ; Wu, Shuilin ; Chu, Paul K. ; Zheng, Yufeng ; To, Michael Kai Tsun ; Leung, Frankie K. L. ; Luk, Keith D. K. ; Cheung, Kenneth M. C. ; Yeung, Kelvin W. K.
刊名	biomaterials
	2013
关键词	Magnesium implant Cyto-compatibility Osteoblast Plasma surface treatment OSTEOPOROTIC FRACTURE ORTHOPEDIC IMPLANTS CORROSION ALLOYS MG BISPHOSPHONATES BIOMATERIALS ARTHROPLASTY REGENERATION MECHANISMS
DOI	10.1016/j.biomaterials.2013.08.052
英文摘要	A newly developed magnesium implant is used to stimulate bone formation in vivo. The magnesium implant after undergoing dual aluminum and oxygen plasma implantation is able to suppress rapid corrosion, leaching of magnesium ions, as well as hydrogen gas release from the biodegradable alloy in simulated body fluid (SBF). No released aluminum is detected from the SBF extract and enhanced corrosion resistance properties are confirmed by electrochemical tests. In vitro studies reveal enhanced growth of GFP mouse osteoblasts on the aluminum oxide coated sample, but not on the untreated sample. In addition to that a small amount (50 ppm) of magnesium ions can enhance osteogenic differentiation as reported previously, our present data show a low concentration of hydrogen can give rise to the same effect. To compare the bone volume change between the plasma-treated magnesium implant and untreated control, micro-computed tomography is performed and the plasma-treated implant is found to induce significant new bone formation adjacent to the implant from day 1 until the end of the animal study. On the contrary, bone loss is observed during the first week post-operation from the untreated magnesium sample. Owing to the protection offered by the Al2O3 layer, the plasma-treated implant degrades more slowly and the small amount of released magnesium ions stimulate new bone formation locally as revealed by histological analyses. Scanning electron microscopy discloses that the Al2O3 layer at the bone-implant interface is still present two months after implantation. In addition, no inflammation or tissue necrosis is observed from both treated and untreated implants. These promising results suggest that the plasma-treated magnesium implant can stimulate bone formation in vivo in a minimal invasive way and without causing post-operative complications. (C) 2013 Elsevier Ltd. All rights reserved.; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); EI; 9; ARTICLE; 38; 9863-9876; 34
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/219191]
专题	工学院
推荐引用方式 GB/T 7714	Wong, Hoi Man,Zhao, Ying,Tam, Vivian,et al. In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants[J]. biomaterials,2013.
APA	Wong, Hoi Man.,Zhao, Ying.,Tam, Vivian.,Wu, Shuilin.,Chu, Paul K..,...&Yeung, Kelvin W. K..(2013).In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants.biomaterials.
MLA	Wong, Hoi Man,et al."In vivo stimulation of bone formation by aluminum and oxygen plasma surface-modified magnesium implants".biomaterials (2013).