Hyperactive external awareness against hypoactive internal awareness in   disorders of consciousness using resting-state functional MRI:   highlighting the involvement of visuo-motor modulation

doi:10.1002/nbm.3130

CORC > 北京大学 > 工学院

	Hyperactive external awareness against hypoactive internal awareness in disorders of consciousness using resting-state functional MRI: highlighting the involvement of visuo-motor modulation
	He, Jiang-Hong ; Yang, Yi ; Zhang, Yi ; Qiu, Si-You ; Zhou, Zhen-Yu ; Dang, Yuan-Yuan ; Dai, Yi-Wu ; Liu, Yi-Jun ; Xu, Ru-Xiang
刊名	生物医学中的核磁共振
	2014
关键词	disorders of consciousness (DOC) vegetative state minimally conscious state internal and external awareness networks functional MRI PERSISTENT VEGETATIVE STATE BRAIN-DAMAGED PATIENTS DEFAULT-MODE NETWORK CONNECTIVITY OWN NAME SELF CORTEX FMRI FLUCTUATIONS HYPOTHESIS
DOI	10.1002/nbm.3130
英文摘要	Resting-state functional MRI (fMRI) has emerged as a valuable tool to characterize the complex states encompassing disorders of consciousness (DOC). Awareness appears to comprise two coexistent, anticorrelated components named the external and internal awareness networks. The present study hypothesizes that DOC interrupts the balance between the internal and external awareness networks. To gain more understanding of this phenomenon, the present study analyzed resting-state fMRI data from 12 patients with DOC versus 12 healthy age-matched controls. The data were explored using independent component analysis and amplitude of low-frequency fluctuation (ALFF) analysis. The results indicated that DOC deactivated midline areas associated with internal awareness. In addition, external awareness was strengthened in DOC because of increased activation in the insula, lingual gyrus, paracentral and supplementary motor area. The activity patterns suggested strengthened external awareness against weakened internal awareness in DOC. In particular, increased activity found in the insula, lingual gyrus, paracentral and supplementary motor area of patients with DOC implied possible involvement of augmented visuo-motor modulation in these patients. DOC is probably related to hyperactive external awareness opposing hypoactive internal awareness. This unique pattern of brain activity may potentially be a prognostic marker for DOC. Copyright (C) 2014 John Wiley & Sons, Ltd.; Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy; SCI(E); EI; SSCI; 2; ARTICLE; yjliufl@gmail.com; zjxuruxiang@163.com; 8; 880-886; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/210508]
专题	工学院
推荐引用方式 GB/T 7714	He, Jiang-Hong,Yang, Yi,Zhang, Yi,et al. Hyperactive external awareness against hypoactive internal awareness in disorders of consciousness using resting-state functional MRI: highlighting the involvement of visuo-motor modulation[J]. 生物医学中的核磁共振,2014.
APA	He, Jiang-Hong.,Yang, Yi.,Zhang, Yi.,Qiu, Si-You.,Zhou, Zhen-Yu.,...&Xu, Ru-Xiang.(2014).Hyperactive external awareness against hypoactive internal awareness in disorders of consciousness using resting-state functional MRI: highlighting the involvement of visuo-motor modulation.生物医学中的核磁共振.
MLA	He, Jiang-Hong,et al."Hyperactive external awareness against hypoactive internal awareness in disorders of consciousness using resting-state functional MRI: highlighting the involvement of visuo-motor modulation".生物医学中的核磁共振 (2014).