Multifunctional Metal Rattle-Type Nanocarriers for MRI-Guided   Photothermal Cancer Therapy

doi:10.1021/mp500006z

CORC > 北京大学 > 工学院

	Multifunctional Metal Rattle-Type Nanocarriers for MRI-Guided Photothermal Cancer Therapy
	Huang, Yuran ; Wei, Tuo ; Yu, Jing ; Hou, Yanglong ; Cai, Kaiyong ; Liang, Xing-Jie
刊名	molecular pharmaceutics
	2014
关键词	rattles nanocarriers imaging photothermal cancer GOLD NANOPARTICLES FACILE SYNTHESIS IN-VITRO SILICA DELIVERY AGENT BIOMEDICINE NANOSHELLS ABSORPTION NANOCAGES
DOI	10.1021/mp500006z
英文摘要	In the past decade, numerous species of nanomaterials have been developed for biomedical application, especially cancer therapy. Realizing visualized therapy is highly promising now because of the potential of accurate, localized treatment. In this work, we first synthesized metal nanorattles (MNRs), which utilized porous gold shells to carry multiple MR imaging contrast agents, superparamagnetic iron oxide nanoparticles (SPIONs), inside. A fragile wormpore-like silica layer was manipulated to encapsulate 8 nm oleylamine SPIONs and mediate the in situ growth of porous gold shell, and it was finally etched by alkaline solution to obtain the rattle-type nanostructure. As shown in the results, this nanostructure with unique morphology could absorb near-infrared light, convert to heat to kill cells, and inhibit tumor growth. As a carrier for multiple SPIONs, it also revealed good function for T-2-weighted MR imaging in tumor site. Moreover, the rest of the inner space of the gold shell could also introduce potential ability as nanocarriers for other cargos such as chemotherapeutic drugs, which is still under investigation. This metal rattle-type nanocarrier may pave the way for novel platforms for cancer therapy in the future.; Medicine, Research & Experimental; Pharmacology & Pharmacy; SCI(E); 1; ARTICLE; kaiyong_cai@cqu.edu.cn; liangxj@nanoctr.cn; 10; 3386-3394; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/208519]
专题	工学院
推荐引用方式 GB/T 7714	Huang, Yuran,Wei, Tuo,Yu, Jing,et al. Multifunctional Metal Rattle-Type Nanocarriers for MRI-Guided Photothermal Cancer Therapy[J]. molecular pharmaceutics,2014.
APA	Huang, Yuran,Wei, Tuo,Yu, Jing,Hou, Yanglong,Cai, Kaiyong,&Liang, Xing-Jie.(2014).Multifunctional Metal Rattle-Type Nanocarriers for MRI-Guided Photothermal Cancer Therapy.molecular pharmaceutics.
MLA	Huang, Yuran,et al."Multifunctional Metal Rattle-Type Nanocarriers for MRI-Guided Photothermal Cancer Therapy".molecular pharmaceutics (2014).