The synergistic regulation of VEGF-mediated angiogenesis through miR-190   and target genes

doi:10.1261/rna.044651.114

CORC > 北京大学 > 工学院

	The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes
	Hao, Yang ; Yang, Junyu ; Yin, Shenyi ; Zhang, Hanshuo ; Fan, Yu ; Sun, Changhong ; Gu, Jin ; Xi, Jianzhong Jeff
刊名	rna a publication of the rna society
	2014
关键词	miR-190 VEGF angiogenesis synergistic effect metastasis ENDOTHELIAL-CELLS GROWTH-FACTOR MICRORNA CANCER EXPRESSION METASTASIS TUMORIGENESIS INTEGRATION DELIVERY INSIGHTS
DOI	10.1261/rna.044651.114
英文摘要	VEGF is a major contributor to angiogenesis, a vital process in normal growth and development and tumor transition. However, the current clinical efficacy of VEGF inhibitors is limited, and the molecular mechanism underlying VEGF regulation remains to be elucidated. Here we show that miR-190 directly targets a group of angiogenic effectors besides VEGF per se. Noted, these effectors can transcriptionally regulate VEGF expression in an intracellular or intercellular manner, thus demonstrating that miR-190 modulates the VEGF-mediated tumor angiogenesis at three levels. The synergistic effect of miR-190 and its target genes demonstrates a complex but apparently more stable system, allowing for the tight control of the level of VEGF. Finally, we showed that miR-190 significantly suppresses tumor metastasis, especially angiogenesis. Together, these results indicate that miR-190 is a promising antitumor target in clinical applications.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339176800014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; SCI(E); PubMed; 2; ARTICLE; jzxi@pku.edu.cn; 8; 1328-1336; 20
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189353]
专题	工学院
推荐引用方式 GB/T 7714	Hao, Yang,Yang, Junyu,Yin, Shenyi,et al. The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes[J]. rna a publication of the rna society,2014.
APA	Hao, Yang.,Yang, Junyu.,Yin, Shenyi.,Zhang, Hanshuo.,Fan, Yu.,...&Xi, Jianzhong Jeff.(2014).The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes.rna a publication of the rna society.
MLA	Hao, Yang,et al."The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes".rna a publication of the rna society (2014).