Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy   under Magnetic Resonance Imaging Guidance

doi:10.1021/bc500279w

CORC > 北京大学 > 工学院

	Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance
	Fu, Guanglei ; Liu, Wei ; Li, Yanyan ; Jin, Yushen ; Jiang, Lingdong ; Liang, Xiaolong ; Feng, Shanshan ; Dai, Zhifei
刊名	生物共轭化学
	2014
关键词	IRON-OXIDE NANOPARTICLES CANCER-THERAPY THERANOSTIC NANOPARTICLES GOLD NANOPARTICLES CONTRAST AGENTS ABLATION NANOSHELLS NANORODS
DOI	10.1021/bc500279w
英文摘要	This paper reported a core-shell nanotheranostic agent by growing Prussian blue (PB) nanoshells of 3-6 nm around superparamagnetic Fe3O4 nanocores for targeted photothermal therapy of cancer under magnetic resonance imaging (MRI) guidance. Both in vitro and in vivo experiments proved that the Fe3O4@PB core-shell nanoparticles showed significant contrast enhancement for T-2-weighted MRI with the relaxivity value of 58.9 mM(-1).s(-1). Simultaneously, the composite nanoparticles exhibited a high photothermal effect under irradiation of a near-infrared laser due to the strong absorption of PB nanoshells, which led to more than 80% death of HeLa cells with only 0.016 mg.mL(-1) of the nanoparticles with the aid of the magnetic targeting effect. Using tumor-bearing nude mice as the model, the near-infrared laser light ablated the tumor effectively in the presence of the Fe3O4@PB nanopartides and the tumor growth inhibition was evaluated to be 87.2%. Capabilities of MRI, magnetic targeting, and photothermal therapy were thus integrated into a single agent to allow efficient MRI-guided targeted photothermal therapy. Most importantly, both PB and Fe3O4 nanoparticles were already clinically approved drugs, so the Fe3O4@PB nanopartides as a theranostic nanomedicine would be particularly promising for clinical applications in the human body due to the reliable biosafety.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342119900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Multidisciplinary; Chemistry, Organic; SCI(E); PubMed; 20; ARTICLE; zhifei.dai@pku.edu.cn; 9; 1655-1663; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188816]
专题	工学院
推荐引用方式 GB/T 7714	Fu, Guanglei,Liu, Wei,Li, Yanyan,et al. Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance[J]. 生物共轭化学,2014.
APA	Fu, Guanglei.,Liu, Wei.,Li, Yanyan.,Jin, Yushen.,Jiang, Lingdong.,...&Dai, Zhifei.(2014).Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance.生物共轭化学.
MLA	Fu, Guanglei,et al."Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance".生物共轭化学 (2014).