Anti-diabetic effects of emodin involved in the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice

CORC > 新疆生态与地理研究所 > 中国科学院新疆生态与地理研究所 > 中国科学院新疆生态与地理研究所(2010年以前数据)

	Anti-diabetic effects of emodin involved in the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice
	Xue ; Jianfeng ; Ding ; Wenjun ; Liu ; Yan
刊名	FITOTERAPIA
	2010
卷号	81 期号:3 页码:173-177
关键词	ADIPOCYTE DIFFERENTIATION INSULIN-RESISTANCE IN-VITRO EXPRESSION OBESITY CELLS MECHANISMS PATHWAY ALPHA
ISSN号	0367-326X
通讯作者	Ding, WJ, Chinese Acad Sci, Grad Univ, Coll Life Sci, 19 A,Yu Quan Rd, Beijing 100049, Peoples R China
中文摘要	Rheum palmatum unit has been widely applied in the clinical treatment of diabetes mellitus It has been found that emodin as the major bioactive component of R palmatum L exhibits the competency to activate peroxisomal proliferator-activated receptor-gamma (PPAR gamma) in vitro So the aim of this study was to evaluate the anti-diabetic effects of emodin through the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin (STZ)-induced diabetic mice The diabetic mice were intraperitoneally injected with emodin for three weeks No changes of food consumption and the body weight in emodin-treated mice were monitored daily during the entire experiment At the end of experiment. the levels of blood glucose, triglyceride and total cholesterol in serum were significantly decreased after emodin treatment. However, serum high-density lipoprotein cholesterol (HDLc) concentration was significantly elevated The glucose tolerance and insulin sensitivity in emodin-treated group were significantly improved Furthermore, the results of quantitative RT-PCR analysis showed that emodin significantly elevated the mRNA expression level of PPAR gamma and regulated the mRNA expressions of LPL. FAT/CD36, resistin and FABPs (ap2) in liver and adipocyte tissues. No effects on the mRNA expressions of PPAR alpha and PPAR alpha-target genes were observed Taken together, the results suggested that the activation of PPAR gamma and the modulation of metabolism-related genes were likely involved in the anti-diabetic effects of emodin (C) 2009 Elsevier B V All rights reserved
学科主题	生物化学与分子生物学
收录类别	SCI
公开日期	2011-08-19
内容类型	期刊论文
源URL	[http://ir.xjlas.org/handle/365004/9980]
专题	新疆生态与地理研究所_中国科学院新疆生态与地理研究所(2010年以前数据)
推荐引用方式 GB/T 7714	Xue,Jianfeng,Ding,et al. Anti-diabetic effects of emodin involved in the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice[J]. FITOTERAPIA,2010,81(3):173-177.
APA	Xue,Jianfeng,Ding,Wenjun,Liu,&Yan.(2010).Anti-diabetic effects of emodin involved in the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice.FITOTERAPIA,81(3),173-177.
MLA	Xue,et al."Anti-diabetic effects of emodin involved in the activation of PPAR gamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice".FITOTERAPIA 81.3(2010):173-177.