DHA-rich marine microalga Schizochytrium mangrovei possesses anti-ageing   effects on Drosophila melanogaster

doi:10.1016/j.jff.2013.01.038

CORC > 北京大学 > 工学院

	DHA-rich marine microalga Schizochytrium mangrovei possesses anti-ageing effects on Drosophila melanogaster
	Huangfu, Jieqiong ; Liu, Jin ; Peng, Cheng ; Suen, Yung Lee ; Wang, Mingfu ; Jiang, Yue ; Chen, Zhen-Yu ; Chen, Peng
刊名	journal of functional foods
	2013
关键词	Ageing Microalgae Schizochytrium mangrovei Drosophila melanogaster Stress-defense DOCOSAHEXAENOIC ACID ALZHEIMERS-DISEASE LIFE-SPAN LIPID-METABOLISM OIL PREVENTION MUTANT CELLS
DOI	10.1016/j.jff.2013.01.038
英文摘要	Docosahexaenoic acid (DHA) play important roles in the prevention of ageing and ageing-related diseases. In this work, the anti-ageing effect of Schizochytrium mangrovei (SM), a marine microalga with high contents of DHA was investigated for the first time. In vitro results showed that SM enhanced the vitality of healthy pheochromocytoma (PC12) cells, whereas it had no protective effect under H2O2-induced oxidative stress. Meanwhile, SM exerted neuroprotective actions in vivo: the supplementation of SM significantly extended the lifespan of both wild type and SODn108 mutant flies Drosophila melanogaster, and ameliorated the age-related decline of locomotor function. This lifespan-extending activity was associated with the mRNA up-regulation of endogenous stress-defense genes such as CuZn-superoxide dismutase (SOD1) and Mn-superoxide dismutase (SOD2), as well as the down-regulation of Methuselah (MTH) gene. Therefore, it was concluded that the anti-ageing capability of DHA-rich SM was mediated through the cooperation with endogenous stress-defense system rather than the direct interaction with oxidative free radicals. (C) 2013 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319536700038&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Food Science & Technology; SCI(E); 6; ARTICLE; 2; 888-896; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154494]
专题	工学院
推荐引用方式 GB/T 7714	Huangfu, Jieqiong,Liu, Jin,Peng, Cheng,et al. DHA-rich marine microalga Schizochytrium mangrovei possesses anti-ageing effects on Drosophila melanogaster[J]. journal of functional foods,2013.
APA	Huangfu, Jieqiong.,Liu, Jin.,Peng, Cheng.,Suen, Yung Lee.,Wang, Mingfu.,...&Chen, Peng.(2013).DHA-rich marine microalga Schizochytrium mangrovei possesses anti-ageing effects on Drosophila melanogaster.journal of functional foods.
MLA	Huangfu, Jieqiong,et al."DHA-rich marine microalga Schizochytrium mangrovei possesses anti-ageing effects on Drosophila melanogaster".journal of functional foods (2013).