PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for   Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of   Cancer

doi:10.1002/adfm.201402338

CORC > 北京大学 > 工学院

	PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer
	Liang, Xiaolong ; Li, Yanyan ; Li, Xiaoda ; Jing, Lijia ; Deng, Zijian ; Yue, Xiuli ; Li, Changhui ; Dai, Zhifei
刊名	先进功能材料
	2015
关键词	MRI CONTRAST AGENTS IN-VIVO GOLD NANOCAGES MULTIFUNCTIONAL NANOPARTICLES PHOTOACOUSTIC MICROSCOPY THERANOSTIC APPLICATIONS ORGANIC NANOPARTICLES POLYMER NANOPARTICLES SURFACE-CHEMISTRY ABLATION THERAPY
DOI	10.1002/adfm.201402338
英文摘要	Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual-modal magnetic resonance imaging (MRI) and photoacoustic imaging guided photothermal therapy of cancer, from a mixture of pyrrole and pyrrole-1-propanoic acid through a facile one-step aqueous dispersion polymerization, followed by covalent attachment of gadolinium chelate, using polyethylene glycol as a linker. The obtained PEGylated polypyrrole nanoparticles conjugating gadolinium chelates (Gd-PEG-PPy NPs), sized around around 70 nm, exhibited a high T-1 relaxivity coefficient of 10.61 L mM(-1) s(-1), more than twice as high as that of the relating free Gd3+ complex (4.2 L mM(-1) s(-1)). After 24 h intravenous injection of Gd-PEG-PPy NPs, the tumor sites exhibited obvious enhancement in both T-1-weighted MRI intensity and photoacoustic signal compared with that before injection, indicating the efficient accumulation of Gd-PEG-PPy NPs due to the introduction of the PEG layer onto the particle surface. In addition, tumor growth could be effectively inhibited after treatment with Gd-PEG-PPy NPs in combination with near-infrared laser irradiation. The passive targeting and high MRI/photoacoustic contrast capability of Gd-PEG-PPy NPs are quite favorable for precise cancer diagnosing and locating the tumor site to guide the external laser irradiation for photothermal ablation of tumors without damaging the surrounding healthy tissues. Therefore, Gd-PEG-PPy NPs may assist in better monitoring the therapeutic process, and contribute to developing more effective "personalized medicine,"showing great potential for cancer diagnosis and therapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350541700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter; SCI(E); EI; 17; ARTICLE; xiaolong.liang@moon.ibp.ac.cn; zhifei.dai@pku.edu.cn; 9; 1451-1462; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154075]
专题	工学院
推荐引用方式 GB/T 7714	Liang, Xiaolong,Li, Yanyan,Li, Xiaoda,et al. PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer[J]. 先进功能材料,2015.
APA	Liang, Xiaolong.,Li, Yanyan.,Li, Xiaoda.,Jing, Lijia.,Deng, Zijian.,...&Dai, Zhifei.(2015).PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer.先进功能材料.
MLA	Liang, Xiaolong,et al."PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer".先进功能材料 (2015).