Antiaging Effects of Astaxanthin-Rich Alga Haematococcus pluvialis on   Fruit Flies under Oxidative Stress

doi:10.1021/jf402224w

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	Antiaging Effects of Astaxanthin-Rich Alga Haematococcus pluvialis on Fruit Flies under Oxidative Stress
	Huangfu, Jieqiong ; Liu, Jin ; Sun, Zheng ; Wang, Mingfu ; Jiang, Yue ; Chen, Zhen-Yu ; Chen, Feng
刊名	农业化学与食品化学杂志
	2013
关键词	aging microalgae Haematococcus pluvialis antioxidant astaxanthin Drosophila melanogaster LIFE-SPAN DROSOPHILA-MELANOGASTER METABOLISM CHEMISTRY BENEFITS
DOI	10.1021/jf402224w
英文摘要	The microalga Haematococcus pluvialis (HP) is the best natural producer of astaxanthin (AX), which is a potent antioxidant with broad health benefits. The present study investigated the antiaging potential of HP biomass using the fruit fly Drosophila melanogaster as the animal model. The results showed that in wild-type flies the treatment of HP induced the early mortality at a concentration of 20 mg/mL, which was associated with the decreased enzymatic activities of CuZn-superoxide dismutase (SOD1) and Mn-superoxide dismutase (SOD2) as well as the down-regulation of SOD 1, SOD2, and catalase (CAT) at the transcriptional level. In SODn108 mutant flies, the supplementation of HP (10 or 20 mg/mL) significantly extended their lifespan and ameliorated the age-related decline in locomotor function. Further studies suggested that HP may play a role as a complement to the defective endogenous antioxidant system to exert such lifespan elongation effects. These results, taken together, strongly support the antiaging properties of HP and its therapeutic rather than preventive potential against aging-related diseases.; Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology; SCI(E); EI; PubMed; 3; ARTICLE; 32; 7800-7804; 61
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153920]
专题	工学院
推荐引用方式 GB/T 7714	Huangfu, Jieqiong,Liu, Jin,Sun, Zheng,et al. Antiaging Effects of Astaxanthin-Rich Alga Haematococcus pluvialis on Fruit Flies under Oxidative Stress[J]. 农业化学与食品化学杂志,2013.
APA	Huangfu, Jieqiong.,Liu, Jin.,Sun, Zheng.,Wang, Mingfu.,Jiang, Yue.,...&Chen, Feng.(2013).Antiaging Effects of Astaxanthin-Rich Alga Haematococcus pluvialis on Fruit Flies under Oxidative Stress.农业化学与食品化学杂志.
MLA	Huangfu, Jieqiong,et al."Antiaging Effects of Astaxanthin-Rich Alga Haematococcus pluvialis on Fruit Flies under Oxidative Stress".农业化学与食品化学杂志 (2013).