Mild Anastomotic Stenosis in Patient-Specific CABG Model May Enhance   Graft Patency: A New Hypothesis

doi:10.1371/journal.pone.0073769

CORC > 北京大学 > 工学院

	Mild Anastomotic Stenosis in Patient-Specific CABG Model May Enhance Graft Patency: A New Hypothesis
	Huo, Yunlong ; Luo, Tong ; Guccione, Julius M. ; Teague, Shawn D. ; Tan, Wenchang ; Navia, Jose A. ; Kassab, Ghassan S.
刊名	plos one
	2013
关键词	CORONARY ARTERIAL TREE LONG-TERM PATENCY BYPASS GRAFT INTIMAL HYPERPLASIA NEOINTIMAL HYPERPLASIA VEIN GRAFTS BLOOD-FLOW DISTAL ANASTOMOSES SAPHENOUS-VEIN WALL SHEAR
DOI	10.1371/journal.pone.0073769
英文摘要	It is well known that flow patterns at the anastomosis of coronary artery bypass graft (CABG) are complex and may affect the long-term patency. Various attempts at optimal designs of anastomosis have not improved long-term patency. Here, we hypothesize that mild anastomotic stenosis (area stenosis of about 40-60%) may be adaptive to enhance the hemodynamic conditions, which may contribute to slower progression of atherosclerosis. We further hypothesize that proximal/distal sites to the stenosis have converse changes that may be a risk factor for the diffuse expansion of atherosclerosis from the site of stenosis. Twelve (12) patient-specific models with various stenotic degrees were extracted from computed tomography images using a validated segmentation software package. A 3-D finite element model was used to compute flow patterns including wall shear stress (WSS) and its spatial and temporal gradients (WSS gradient, WSSG, and oscillatory shear index, OSI). The flow simulations showed that mild anastomotic stenosis significantly increased WSS (> 15 dynes.cm(-2)) and decreased OSI (< 0.02) to result in a more uniform distribution of hemodynamic parameters inside anastomosis albeit proximal/distal sites to the stenosis have a decrease of WSS (< 4 dynes.cm(-2)). These findings have significant implications for graft adaptation and long-term patency.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324408400034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 2; ARTICLE; 9; e73769; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153883]
专题	工学院
推荐引用方式 GB/T 7714	Huo, Yunlong,Luo, Tong,Guccione, Julius M.,et al. Mild Anastomotic Stenosis in Patient-Specific CABG Model May Enhance Graft Patency: A New Hypothesis[J]. plos one,2013.
APA	Huo, Yunlong.,Luo, Tong.,Guccione, Julius M..,Teague, Shawn D..,Tan, Wenchang.,...&Kassab, Ghassan S..(2013).Mild Anastomotic Stenosis in Patient-Specific CABG Model May Enhance Graft Patency: A New Hypothesis.plos one.
MLA	Huo, Yunlong,et al."Mild Anastomotic Stenosis in Patient-Specific CABG Model May Enhance Graft Patency: A New Hypothesis".plos one (2013).