Developing Fe3O4 nanoparticles into an efficient multimodality imaging   and therapeutic probe

doi:10.1039/c3nr04157c

CORC > 北京大学 > 工学院

	Developing Fe3O4 nanoparticles into an efficient multimodality imaging and therapeutic probe
	Hao, Rui ; Yu, Jing ; Ge, Zigang ; Zhao, Lingyun ; Sheng, Fugeng ; Xu, Lili ; Li, Gongjie ; Hou, Yanglong
刊名	nanoscale
	2013
关键词	IRON-OXIDE NANOPARTICLES MRI CONTRAST AGENTS MAGNETIC NANOPARTICLES HYPERTHERMIA TREATMENT WATER NANOCRYSTALS T-1 EXCHANGE SHELL FIELD
DOI	10.1039/c3nr04157c
英文摘要	A rapid ligand-exchange method was developed to transfer high quality hydrophobic magnetite nanocrystals into water-soluble NPs by using protocatechuic acid as a ligand via homogenous reaction. After ligand exchange, the magnetite nanocrystals not only exhibited outstanding stability in water, but also maintained high crystallinity and saturation magnetization. Cell viability experiments demonstrated good biocompatibility of the NPs. For 12 nm magnetite nanoparticles (NPs), the small hydrodynamic size of 14 nm enabled a high T-1 relaxivity of 17.8 mM(-1) s(-1) while high saturation magnetization of 77.8 emu g(-1) enabled the NPs to exhibit a high T-2 relaxivity of 220 mM(-1) s(-1) in MRI phantom experiments. In vivo MR imaging experiments further confirmed that the NPs were eminent T-1 and T-2 contrast agents. Moreover, the high quality NPs can be used as excellent magnetic heating agents under an alternating magnetic field. With all those features, including multimodality imaging and magnetic hyperthermia, the NPs can be used as single compound multifunctional agents for various biomedical applications, especially for cancer diagnosis and therapy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326982000076&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; SCI(E); EI; PubMed; 13; ARTICLE; 23; 11954-11963; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153870]
专题	工学院
推荐引用方式 GB/T 7714	Hao, Rui,Yu, Jing,Ge, Zigang,et al. Developing Fe3O4 nanoparticles into an efficient multimodality imaging and therapeutic probe[J]. nanoscale,2013.
APA	Hao, Rui.,Yu, Jing.,Ge, Zigang.,Zhao, Lingyun.,Sheng, Fugeng.,...&Hou, Yanglong.(2013).Developing Fe3O4 nanoparticles into an efficient multimodality imaging and therapeutic probe.nanoscale.
MLA	Hao, Rui,et al."Developing Fe3O4 nanoparticles into an efficient multimodality imaging and therapeutic probe".nanoscale (2013).