The brain interstitial system: Anatomy, modeling, in vivo measurement,   and applications

doi:10.1016/j.pneurobio.2015.12.007

CORC > 北京大学 > 信息科学技术学院

	The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications
	Lei, Yiming ; Han, Hongbin ; Yuan, Fan ; Javeed, Aqeel ; Zhao, Yong
刊名	International Conference on Aging and Disease (ICAD)
	2017
关键词	Brain interstitial system Extracellular space Biophysical modeling Brain interstitial division In vivo measurement CONVECTION-ENHANCED DELIVERY CENTRAL-NERVOUS-SYSTEM CEREBROSPINAL-FLUID CIRCULATION EXTRACELLULAR-SPACE DIFFUSION CEREBRAL AMYLOID ANGIOPATHY INDIVIDUAL CHROMAFFIN CELLS ALZHEIMERS-DISEASE BRAIN DEEP CERVICAL LYMPH PERINEURONAL NETS RAT-BRAIN
DOI	10.1016/j.pneurobio.2015.12.007
英文摘要	Although neurons, attract the most attention in neurobiology, our current knowledge of neural circuit can only partially explain the neurological and psychiatric conditions of the brain. Thus, it is also important to consider the influence of brain interstitial system (ISS), which refers to the space among neural cells and capillaries. The ISS is the major compartment of the brain microenvironment that provides the immediate accommodation space for neural cells, and it occupies 15% to 20% of the total brain volume. The brain ISS is a dynamic and complex space connecting the vascular system and neural networks and it plays crucial roles in substance transport and signal transmission among neurons. Investigation of the brain ISS can provide new perspectives for understanding brain architecture and function and for exploring new strategies to treat brain disorders. This review discussed the anatomy of the brain ISS under both physiological and pathological conditions, biophysical modeling of the brain ISS and in vivo measurement and imaging techniques, including recent findings on brain ISS divisions. Moreover, the implications of ISS knowledge for basic neuroscience and clinical applications are addressed. (C) 2016 The Authors. Published by Elsevier Ltd.; National Natural Science Foundation of China (NSFC) [91330103, 61450004, 61470005]; SCI(E); PubMed; ARTICLE; ,SI; 230-246; 157
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435108]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Lei, Yiming,Han, Hongbin,Yuan, Fan,et al. The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications[J]. International Conference on Aging and Disease (ICAD),2017.
APA	Lei, Yiming,Han, Hongbin,Yuan, Fan,Javeed, Aqeel,&Zhao, Yong.(2017).The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications.International Conference on Aging and Disease (ICAD).
MLA	Lei, Yiming,et al."The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications".International Conference on Aging and Disease (ICAD) (2017).