Behavioral and neurobiological abnormalities induced by social isolation as a useful animal model of schizophrenia

CORC > 北京大学 > 信息科学技术学院

	Behavioral and neurobiological abnormalities induced by social isolation as a useful animal model of schizophrenia
	Lei Ming ; Luo Lu ; Ma Shi-Qi ; Zhang Yan ; Wu Xi-Hong ; Li Liang
刊名	sheng li xue bao acta physiologica sinica
	2013
英文摘要	Social isolation influences the development of the brain, causing dysfunctions at behavioral, cellular and molecular levels. The present paper summarizes the abnormalities induced by social isolation in behaviors, neurotransmitters and cell apoptosis. At the behavioral level, social isolation induces hyperlocomotion, abnormalities in startle reflex and prepulse inhibition (PPI), and dysfunctions in conditioned learning, reversal learning and memory. Moreover, social isolation causes changes of neurotransmitters, such as the increase of dopamine in the nucleus accumbens, the amygdala and other brain regions in the limbic system, the decrease of dopamine in medial prefrontal cortex, the decrease of 5-HT in the nucleus accumbens and the hippocampus, and changes of glutamine in the prefrontal cortex. Finally, social isolation affects cell apoptosis in different brain areas, such as the medial prefrontal cortex, amygdala, nucleus accumbens, and hippocampus. Both the changes in neurotransmitters and cell apoptosis may contribute to the behavioral dysfunctions in social isolated rats. Since schizophrenic patients have similar abnormalities in behaviors and neurotransmitters, isolation rearing can be used as a useful animal model of schizophrenia.; PubMed; 0; 1; 101-8; 65
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342955]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Lei Ming,Luo Lu,Ma Shi-Qi,et al. Behavioral and neurobiological abnormalities induced by social isolation as a useful animal model of schizophrenia[J]. sheng li xue bao acta physiologica sinica,2013.
APA	Lei Ming,Luo Lu,Ma Shi-Qi,Zhang Yan,Wu Xi-Hong,&Li Liang.(2013).Behavioral and neurobiological abnormalities induced by social isolation as a useful animal model of schizophrenia.sheng li xue bao acta physiologica sinica.
MLA	Lei Ming,et al."Behavioral and neurobiological abnormalities induced by social isolation as a useful animal model of schizophrenia".sheng li xue bao acta physiologica sinica (2013).