The progress and prospect of prepulse inhibition in autism

CORC > 北京大学 > 信息科学技术学院

	The progress and prospect of prepulse inhibition in autism
	Wu Zhe-Meng ; Lei Ming ; Wu Xi-Hong ; Li Liang
刊名	sheng li xue bao acta physiologica sinica
	2014
英文摘要	Prepulse inhibition (PPI) is suppression of the startle reflex when an intense startling stimulus is preceded by a weaker sensory stimulus (the prepulse). It is an operational measurement of sensorimotor gating mechanism to help human adapt to complex environment. This weak prepulse protect central cognitive processing by damping the effect of intense stimuli. Autistics cannot select out behaviorally important information from a lot of irrelevant resources and reflect abnormal gating mechanism and attentional abnormalities. Previous studies have not made agreement on whether autistic patients demonstrated deficits in PPI, because the results depend on age, sex, severity of the disease as well as the experimental parameters used. Moreover, these studies have not covered whether autistics have suffered deficits in higher-order processing. In this review, the "top-down" modulation of selective attention and subjective emotion are introduced into the PPI experiment. We also introduce fear conditioning and perceived spatial separation paradigm to further explore the interaction between autistic cognitive process and gating mechanism.; PubMed; 0; 6; 730-8; 66
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341738]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Wu Zhe-Meng,Lei Ming,Wu Xi-Hong,et al. The progress and prospect of prepulse inhibition in autism[J]. sheng li xue bao acta physiologica sinica,2014.
APA	Wu Zhe-Meng,Lei Ming,Wu Xi-Hong,&Li Liang.(2014).The progress and prospect of prepulse inhibition in autism.sheng li xue bao acta physiologica sinica.
MLA	Wu Zhe-Meng,et al."The progress and prospect of prepulse inhibition in autism".sheng li xue bao acta physiologica sinica (2014).