Multi-component continuous separation chip composed of micropillar   arrays in a split-level spiral channel

doi:10.1039/c3ra41906a

CORC > 北京大学 > 信息科学技术学院

	Multi-component continuous separation chip composed of micropillar arrays in a split-level spiral channel
	Geng, Zhaoxin ; Ju, Yanrui ; Wang, Qifeng ; Wang, Wei ; Li, Zhihong
刊名	rsc advances
	2013
关键词	BLOOD MICROCHANNEL SIZE FLOW FRACTIONATION FILTRATION PARTICLE CELLS
DOI	10.1039/c3ra41906a
英文摘要	The separation and concentration of blood components or biological functional microparticles, have become indispensable in various biomedical and environmental applications. In this paper, a chip with two rows of micropillar arrays along a spiral-channel, in which plasma and various blood cells with different sizes can be separated or enriched simultaneously, has been achieved. The proposed method combines crossflow, centrifugation and size-selective separation approaches. Specially, a 40 mm-high step, which can increase the pressure difference, is designed between the inner and middle channel to enhance the separation efficiency and purity. In the chip with split-level channels, the number of red blood cells (RBCs) gathered from the inner outlet decreased significantly, and the collected plasma volume increased, compared to those in the plain one.; Chemistry, Multidisciplinary; SCI(E); EI; 3; ARTICLE; 34; 14798-14806; 3
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/152372]
专题	信息科学技术学院工学院
推荐引用方式 GB/T 7714	Geng, Zhaoxin,Ju, Yanrui,Wang, Qifeng,et al. Multi-component continuous separation chip composed of micropillar arrays in a split-level spiral channel[J]. rsc advances,2013.
APA	Geng, Zhaoxin,Ju, Yanrui,Wang, Qifeng,Wang, Wei,&Li, Zhihong.(2013).Multi-component continuous separation chip composed of micropillar arrays in a split-level spiral channel.rsc advances.
MLA	Geng, Zhaoxin,et al."Multi-component continuous separation chip composed of micropillar arrays in a split-level spiral channel".rsc advances (2013).