Electrically-Evoked Frequency-Following Response (EFFR) in the Auditory   Brainstem of Guinea Pigs

doi:10.1371/journal.pone.0106719

CORC > 北京大学 > 信息科学技术学院

	Electrically-Evoked Frequency-Following Response (EFFR) in the Auditory Brainstem of Guinea Pigs
	He, Wenxin ; Ding, Xiuyong ; Zhang, Ruxiang ; Chen, Jing ; Zhang, Daoxing ; Wu, Xihong
刊名	plos one
	2014
关键词	INFERIOR COLLICULUS COCHLEAR IMPLANT POTENTIALS HEARING NERVE SPEECH TONES ABR STIMULATION ARTIFACT
DOI	10.1371/journal.pone.0106719
英文摘要	It is still a difficult clinical issue to decide whether a patient is a suitable candidate for a cochlear implant and to plan postoperative rehabilitation, especially for some special cases, such as auditory neuropathy. A partial solution to these problems is to preoperatively evaluate the functional integrity of the auditory neural pathways. For evaluating the strength of phase-locking of auditory neurons, which was not reflected in previous methods using electrically evoked auditory brainstem response (EABR), a new method for recording phase-locking related auditory responses to electrical stimulation, called the electrically evoked frequency-following response (EFFR), was developed and evaluated using guinea pigs. The main objective was to assess feasibility of the method by testing whether the recorded signals reflected auditory neural responses or artifacts. The results showed the following: 1) the recorded signals were evoked by neuron responses rather than by artifact; 2) responses evoked by periodic signals were significantly higher than those evoked by the white noise; 3) the latency of the responses fell in the expected range; 4) the responses decreased significantly after death of the guinea pigs; and 5) the responses decreased significantly when the animal was replaced by an electrical resistance. All of these results suggest the method was valid. Recording obtained using complex tones with a missing fundamental component and using pure tones with various frequencies were consistent with those obtained using acoustic stimulation in previous studies.; Multidisciplinary Sciences; SCI(E); PubMed; 0; ARTICLE; chenj@cis.pku.edu.cn; wxh@cis.pku.edu.cn; 9; e106719; 9
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/151787]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	He, Wenxin,Ding, Xiuyong,Zhang, Ruxiang,et al. Electrically-Evoked Frequency-Following Response (EFFR) in the Auditory Brainstem of Guinea Pigs[J]. plos one,2014.
APA	He, Wenxin,Ding, Xiuyong,Zhang, Ruxiang,Chen, Jing,Zhang, Daoxing,&Wu, Xihong.(2014).Electrically-Evoked Frequency-Following Response (EFFR) in the Auditory Brainstem of Guinea Pigs.plos one.
MLA	He, Wenxin,et al."Electrically-Evoked Frequency-Following Response (EFFR) in the Auditory Brainstem of Guinea Pigs".plos one (2014).