Comparisons of Ultrafine and Fine Particles in Their Associations with   Biomarkers Reflecting Physiological Pathways

doi:10.1021/es5006016

CORC > 北京大学 > 环境科学与工程学院

	Comparisons of Ultrafine and Fine Particles in Their Associations with Biomarkers Reflecting Physiological Pathways
	Gong, Jicheng ; Zhu, Tong ; Kipen, Howard ; Wang, Guangfa ; Hu, Min ; Guo, Qingfeng ; Ohman-Strickland, Pamela ; Lu, Shou-En ; Wang, Yuedan ; Zhu, Ping ; Rich, David Q. ; Huang, Wei ; Zhang, Junfeng
刊名	environmental science technology
	2014
关键词	PARTICULATE AIR-POLLUTION HEALTHY-YOUNG ADULTS OXIDATIVE STRESS BEIJING OLYMPICS CARDIOVASCULAR-DISEASE NUMBER CONCENTRATIONS EXPOSURE ASSESSMENT AMBIENT ULTRAFINE MORTALITY CALIFORNIA
DOI	10.1021/es5006016
英文摘要	Using a quasi-experimental opportunity offered by greatly restricted air pollution emissions during the Beijing Olympics compared to before and after the Olympics, we conducted the current study to compare ultrafine particles (UFPs) and fine particles (PM2.5) in their associations with biomarkers reflecting multiple pathophysiological pathways linking exposure and cardiorespiratory events. Number concentrations of particles (13.0-764.7 nm) and mass concentrations of PM2.5 were measured at two locations within 9 km from the residence and workplace of 125 participating Beijing residents. Each participant was measured 6 times for biomarkers of autonomic function (heart rate, systolic and diastolic blood pressures), hemostasis (von Willebrand factor, soluble CD40 ligand, and P-selectin), pulmonary inflammation and oxidative stress (exhaled nitric oxide and exhaled breath condensate pH, malondialdehyde, and nitrite), and systemic inflammation and oxidative stress (urinary malondialdehyde and 8-hydroxy-2'-deoxyguanosine, plasma fibrinogen, and white blood cells). Linear mixed models were used to estimate associations of biomarkers with UFPs and PM2.5 measured 1-7 days prior to biomarker measurements (lags). We found that the correlation coefficient for UFPs at two locations (similar to 9 km apart) was 0.45, and at the same location, the correlation coefficient for PM2.5 vs UFPs was -0.18. Changes in biomarker levels associated with increases in UFPs and PM2.5 were comparable in magnitude. However, associations of certain biomarkers with UFPs had different lag patterns compared to those with PM2.5, suggesting that the ultrafine size fraction (<= 100 nm) and the fine size fraction (similar to 100 nm to 2.5 mu m) of PM2.5 are likely to affect PM-induced pathophysiological pathways independently.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335720100075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; 14; ARTICLE; junfeng.zhang@duke.edu; 9; 5264-5273; 48
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/212794]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Gong, Jicheng,Zhu, Tong,Kipen, Howard,et al. Comparisons of Ultrafine and Fine Particles in Their Associations with Biomarkers Reflecting Physiological Pathways[J]. environmental science technology,2014.
APA	Gong, Jicheng.,Zhu, Tong.,Kipen, Howard.,Wang, Guangfa.,Hu, Min.,...&Zhang, Junfeng.(2014).Comparisons of Ultrafine and Fine Particles in Their Associations with Biomarkers Reflecting Physiological Pathways.environmental science technology.
MLA	Gong, Jicheng,et al."Comparisons of Ultrafine and Fine Particles in Their Associations with Biomarkers Reflecting Physiological Pathways".environmental science technology (2014).