Deficits of perceived spatial separation induced prepulse inhibition in   patients with schizophrenia: relationships to symptoms and   neurocognition

doi:10.1186/s12888-017-1276-4

CORC > 北京大学 > 心理与认知科学学院

	Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition
	Yang, Ning-Bo ; Tian, Qing ; Fan, Yu ; Bo, Qi-Jing ; Zhang, Liang ; Li, Liang ; Wang, Chuan-Yue
刊名	BMC PSYCHIATRY
	2017
关键词	Schizophrenia Prepulse inhibition Perceived spatial separation Clinical symptom Thought disorder Cognitive function Attentional function ATTENTIONAL MODULATION ACOUSTIC STARTLE LATENT INHIBITION GATING DEFICITS OLDER-ADULTS REFLEX RECOGNITION INTEGRATION MECHANISMS PRESTIMULI
DOI	10.1186/s12888-017-1276-4
英文摘要	Background: Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings about the relationship between PPI and clinical symptoms, cognitive performances have been equivocal. Methods: Seventy-five schizophrenia patients (SZ) and 50 healthy controls (HC) were assessed in a modified acoustic PPI paradigm, named perceived spatial separation-induced PPI (PSS-PPI), compared to perceived spatial co-location PPI (PSC-PPI) with inter-stimulus interval (ISI) of 120 ms. Repeatable Battery for the Assessment of Neuropsychological Status and the Stroop Color-Word Test were administered to all subjects. Results: Significant decrease in the modified PPI was found in the patients as compared to the controls, and effect sizes (Cohen'd) for patients vs. HCs % PPI levels achieved a significant level (PSC-PPI d = 0.84, PSS-PPI d = 1.27). A logistic regression model based on PSS-PPI significantly represented the diagnostic grouping (X-2 = 29.3; p < 0.001), with 85.2% area under ROC curve in predicting group membership. In addition, patients exhibited deficits in neurocognition. Among patients of "non-remission", after controlling for gender, age, education, duration, recurrence times, onset age, cigarettes per day and chlorpromazine equivalent dosage, PSS-PPI levels were associated with positive and negative symptoms, PANSS total and thought disorder (P1, P6, P7, N5, N7, G9). In multiple linear regression analyses, male and higher attention scores contributed to better PSC-PPI and PSS-PPI in controls group, while larger amount of smoke and longer word-color interfere time contributed to poor PSS-PPI. In patients' group, higher education and attention scores contributed to better PSS-PPI, while repeated relapse contributed to poor PSS-PPI. Conclusions: The acoustic perceived spatial separation-induced PPIs may bring to light the psychopathological symptoms, especially for thought disorder, and the mechanism(s) of the novel PPI paradigm was associated with attention function.; National Natural Science Foundation of China [81471365]; Beijing Municipal Science & Tech Commission [Z161100002616017]; Beijing Institute for Brain Disorders [PXM2015_014226_000051]; Beijing Municipal Administration of Hospitals [ZYLX201403, 2011-2012-02]; SCI(E); SSCI; ARTICLE; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469258]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Yang, Ning-Bo,Tian, Qing,Fan, Yu,et al. Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition[J]. BMC PSYCHIATRY,2017.
APA	Yang, Ning-Bo.,Tian, Qing.,Fan, Yu.,Bo, Qi-Jing.,Zhang, Liang.,...&Wang, Chuan-Yue.(2017).Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition.BMC PSYCHIATRY.
MLA	Yang, Ning-Bo,et al."Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition".BMC PSYCHIATRY (2017).