The association between well-being and the COMT gene: Dispositional   gratitude and forgiveness as mediators

doi:10.1016/j.jad.2017.03.005

CORC > 北京大学 > 心理与认知科学学院

	The association between well-being and the COMT gene: Dispositional gratitude and forgiveness as mediators
	Liu, Jinting ; Gong, Pingyuan ; Gao, Xiaoxue ; Zhou, Xiaolin
刊名	JOURNAL OF AFFECTIVE DISORDERS
	2017
关键词	COMT Well-being Depression Gratitude Forgiveness O-METHYLTRANSFERASE COMT VAL158MET POLYMORPHISM LIFE SATISFACTION DECISION-MAKING POSITIVE AFFECT DEPRESSION HAPPINESS WOMEN DIFFERENCE EMOTIONS
DOI	10.1016/j.jad.2017.03.005
英文摘要	Backround: Previous studies have demonstrated the contributions of genetic variants and positive psychological traits (e.g. gratitude and forgiveness) to well-being. However, little is known about how genes interact with positive traits to affect well-being. Methods: To investigate to what extent the COMTVa1158Met polymorphism modulates well-being and to what extent dispositional gratitude and forgiveness mediate the individual differences in well-being, 445 participants were recruited and required to complete a battery of questionnaires. Results: We found that individuals with a smaller number of the Met alleles reported greater well-being, less depressive symptoms, and greater tendencies for gratitude and forgiveness. Moreover, dispositional gratitude and forgiveness mediated the genotype effects on well-being and depressive symptoms. These results remained significant after controlling for non-genetic factors (socioeconomic status, religious beliefs, romantic relationship status, parenting style). Limitation: The sample size limits the generalizability of results. Conclusion: This study demonstrates the contribution of the COMT Va1158Met polymorphism to individual differences in well-being and suggests a potential psychobiological pathway from dopaminergic and noradrenergic systems to happiness.; National Basic Research Program of China (973 Program) [2015CB856400]; National Natural Science Foundation of China [31630034, 31600928]; Natural Science Foundation of China [31640037]; China Postdoctoral Science Foundation [2015M582399]; SCI(E); SSCI; ARTICLE; 115-121; 214
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469240]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Liu, Jinting,Gong, Pingyuan,Gao, Xiaoxue,et al. The association between well-being and the COMT gene: Dispositional gratitude and forgiveness as mediators[J]. JOURNAL OF AFFECTIVE DISORDERS,2017.
APA	Liu, Jinting,Gong, Pingyuan,Gao, Xiaoxue,&Zhou, Xiaolin.(2017).The association between well-being and the COMT gene: Dispositional gratitude and forgiveness as mediators.JOURNAL OF AFFECTIVE DISORDERS.
MLA	Liu, Jinting,et al."The association between well-being and the COMT gene: Dispositional gratitude and forgiveness as mediators".JOURNAL OF AFFECTIVE DISORDERS (2017).