Cognitive dysfunction and epigenetic alterations of the BDNF gene are   induced by social isolation during early adolescence

doi:10.1016/j.bbr.2016.07.025

CORC > 北京大学 > 心理与认知科学学院

	Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
	Li, Man ; Du, Wei ; Shao, Feng ; Wang, Weiwen
刊名	BEHAVIOURAL BRAIN RESEARCH
	2016
关键词	Social isolation Cognitive behaviour Brain-derived neurotrophic factor (BDNF) Epigenetics MEDIAL PREFRONTAL CORTEX NEUROTROPHIC FACTOR EXPRESSION SPATIAL MEMORY PERFORMANCE ACOUSTIC STARTLE RESPONSE PREPULSE INHIBITION ADULT RATS MATERNAL SEPARATION VENTRAL HIPPOCAMPUS THETA-OSCILLATIONS NUCLEUS-ACCUMBENS
DOI	10.1016/j.bbr.2016.07.025
英文摘要	Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either group reared or isolation-reared conditions during post-natal days (PNDs) 21-34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour. (C) 2016 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China [31470988, 81471122]; School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, the Chinese Academy of Sciences [KJZD-EW-L04]; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences; SCI(E); PubMed; ARTICLE; shaof@pku.edu.cn; wangww@psych.ac.cn; 177-183; 313
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/447871]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Li, Man,Du, Wei,Shao, Feng,et al. Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence[J]. BEHAVIOURAL BRAIN RESEARCH,2016.
APA	Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2016).Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence.BEHAVIOURAL BRAIN RESEARCH.
MLA	Li, Man,et al."Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence".BEHAVIOURAL BRAIN RESEARCH (2016).