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	Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats
	Li, Nanxin ; Wu, Xihong ; Li, Liang
刊名	行为药理学
	2007
关键词	animal model clozapine isolation rearing rat reversal learning schizophrenia T maze MEDIAL PREFRONTAL CORTEX CARD SORTING TEST PREPULSE INHIBITION DEFICITS SENSORIMOTOR GATING DEFICITS INDUCED COGNITIVE DEFICITS REARING-INDUCED DEFICITS LONG-TERM EVALUATION SPRAGUE-DAWLEY RATS MORRIS WATER MAZE SOCIAL-ISOLATION
DOI	10.1097/FBP.0b013e3280d3ee83
英文摘要	Isolation rearing has been used for inducing schizophrenia-like symptoms in rats. Human schizophrenics have deficits in prefrontal-dysfunction-related cognitive/behavioral flexibility. Rats with lesions of the medial prefrontal cortex perform poorly in reversal learning. It is uncertain whether isolation rearing, however, causes reversal-learning impairment in adult rats. Using the rotating T maze, this study examined the effect of chronic administration of clozapine on visual discrimination learning and reversal learning in isolation-reared and socially reared adult rats. The results show that isolation-reared rats without clozapine injection performed significantly worse than socially reared rats in reversal learning but not in acquisition learning. Chronic injection of clozapine (5 or 10 mg/kg) in isolation-reared rats significantly improved reversal learning but had no effects on acquisition learning. Further data analyses show that in both the inhibition phase and the new-strategy-acquisition phase of reversal learning, isolation-reared rats needed significantly more correct-response trials to reach the criterion than socially reared rats, and clozapine significantly reduced the isolation-induced impairment of reversal learning only in the new-strategy-acquisition phase. In socially reared rats, clozapine had a dose-related interfering effect on reversal learning but not acquisition learning. This study supports the use of isolation rearing as a model for investigating the neurodevelopmental hypothesis of schizophrenia.; Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy; SCI(E); PubMed; SSCI; 28; REVIEW; 2; 135-145; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/345635]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Li, Nanxin,Wu, Xihong,Li, Liang. Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats[J]. 行为药理学,2007.
APA	Li, Nanxin,Wu, Xihong,&Li, Liang.(2007).Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats.行为药理学.
MLA	Li, Nanxin,et al."Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats".行为药理学 (2007).

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