Maternal Immune Activation Impairs Reversal Learning and Increases Serum   Tumor Necrosis Factor-alpha in Offspring

doi:10.1159/000322455

CORC > 北京大学 > 心理与认知科学学院

	Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring
	Han, Xiao ; Li, Nanxin ; Meng, Qingxuan ; Shao, Feng ; Wang, Weiwen
刊名	neuropsychobiology
	2011
关键词	Maternal immune activation Reversal learning Tumor necrosis factor-alpha Adolescent Schizophrenia ADULT BRAIN SCHIZOPHRENIA RATS LEADS ANTIPSYCHOTICS CHALLENGE PREGNANCY PATHOLOGY EXPOSURE LESIONS
DOI	10.1159/000322455
英文摘要	Maternal immune activation (MIA) produces a variety of behavioral and brain abnormalities in rodent models of several neuropsychiatric disorders. However, it remains controversial whether MIA impairs reversal learning, a basic function of flexibility relevant to those diseases, in offspring. In the present study, we used the Morris water maze to investigate the effects of middle to late gestation stage poly(I:C) challenges on spatial learning and subsequent reversal learning performance in adolescent rats. Maternal poly(I:C) treatment induced deficits in reversal learning without affecting spatial acquisition abilities. In addition, the serum level of the pro-inflammatory cytokine tumor necrosis factor-alpha was increased in MIA rats. This study advances our understanding of how MIA affects adolescent behavior and brain function. Copyright (C) 2011 S. Karger AG, Basel; Neurosciences; Psychiatry; Psychology; SCI(E); PubMed; 14; ARTICLE; 1; 9-14; 64
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/323405]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Han, Xiao,Li, Nanxin,Meng, Qingxuan,et al. Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring[J]. neuropsychobiology,2011.
APA	Han, Xiao,Li, Nanxin,Meng, Qingxuan,Shao, Feng,&Wang, Weiwen.(2011).Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring.neuropsychobiology.
MLA	Han, Xiao,et al."Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring".neuropsychobiology (2011).