The novel oxidative stress marker thioredoxin is increased in   first-episode schizophrenic patients

doi:10.1016/j.schres.2009.05.016

CORC > 北京大学 > 心理与认知科学学院

	The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients
	Zhang, Xiang Yang ; Chen, Da Chun ; Xiu, Mei Hong ; Wang, Fan ; Qi, Ling Yan ; Sun, Hong Qang ; Chen, Song ; He, Shu Chang ; Wu, Gui Ying ; Haile, Colin N. ; Kosten, Therese A. ; Lu, Lin ; Kosten, Thomas R.
刊名	schizophrenia research
	2009
关键词	Schizophrenia Oxidative stress Free radical Thioredoxin Psychopathology ATYPICAL ANTIPSYCHOTIC-DRUGS ANTIOXIDANT DEFENSE SYSTEM BLOOD SUPEROXIDE-DISMUTASE FREE-RADICAL PATHOLOGY TARDIVE-DYSKINESIA LIPID-PEROXIDATION THERAPEUTIC IMPLICATIONS PLASMA THIOREDOXIN REDOX REGULATION DIFFERENT FORMS
DOI	10.1016/j.schres.2009.05.016
英文摘要	Excessive free radical production leading to oxidative stress may be involved in the pathophysiology of schizophrenia. oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative-stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in various stages of schizophrenia. Serum TRX levels were determined using ELISA from 60 never-medicated first-episode and 66 medicated chronic schizophrenia patients and 66 healthy control subjects matched for age and gender. The psychopathology of schizophrenia was assessed by the Positive and Negative Syndrome Scale (PANSS). Our results showed that group comparison between first-episode and chronic patients and control groups revealed significantly increased serum TRX only in first-episode patients. Increased levels of TRX in patients experiencing an acute stage schizophrenic episode was also significantly higher compared to chronic schizophrenic patients on antipsychotic medication. Serum TRX was also positively correlated with positive symptoms of schizophrenia. Our results suggest oxidative stress occurs in an acute stage of schizophrenic episode and may have an important role in pathogenesis and symptomology of schizophrenia. Lower TRX levels in chronic patients treated with antipsychotics may have implications for treatment outcome. (C) 2009 Elsevier B.V. All rights reserved.; Psychiatry; SCI(E); SSCI; 31; ARTICLE; 2-3; 151-157; 113
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/245406]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Zhang, Xiang Yang,Chen, Da Chun,Xiu, Mei Hong,et al. The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients[J]. schizophrenia research,2009.
APA	Zhang, Xiang Yang.,Chen, Da Chun.,Xiu, Mei Hong.,Wang, Fan.,Qi, Ling Yan.,...&Kosten, Thomas R..(2009).The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients.schizophrenia research.
MLA	Zhang, Xiang Yang,et al."The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients".schizophrenia research (2009).