Brief social isolation in early adolescence affects reversal learning   and forebrain BDNF expression in adult rats

doi:10.1016/j.brainresbull.2011.07.008

CORC > 北京大学 > 心理与认知科学学院

	Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats
	Han, Xiao ; Wang, Weiwen ; Xue, Xiaofang ; Shao, Feng ; Li, Nanxin
刊名	脑研究通报
	2011
关键词	Adolescence BDNF Hippocampus Morris water maze Nucleus accumbens Prefrontal cortex Reversal learning Social isolation MEDIAL PREFRONTAL CORTEX SPRAGUE-DAWLEY RATS MORRIS WATER MAZE BEHAVIORAL FLEXIBILITY DORSOMEDIAL STRIATUM NEUROTROPHIC FACTOR SPATIAL MEMORY NUCLEUS-ACCUMBENS RECEPTOR TRKB BRAIN
DOI	10.1016/j.brainresbull.2011.07.008
英文摘要	Isolation rearing produces significant behavioral and neurochemical dysregulations in rodents. However, few studies have examined the effects of short-term isolation rearing during puberty compared to chronic social isolation from weaning to adulthood. In this study, we subjected weaning rats to a brief two-week social isolation and then re-socialized them until adulthood. We found that early isolation rearing affected reversal learning without interfering with spatial learning in the Morris water maze. We also found that brain-derived neurotrophic factor (BDNF) protein expression was increased in the medial prefrontal cortex (mPFC) but was decreased in the nucleus accumbens (NAc), CA1 and dentate gyrus of the hippocampus in isolation-reared rats. Together, our findings support the use of adolescent social isolation as a rodent model to study brain and behavior abnormalities induced by early environmental interruptions. (C) 2011 Elsevier Inc. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296405000006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 18; ARTICLE; 3-4; 173-178; 86
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162813]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Han, Xiao,Wang, Weiwen,Xue, Xiaofang,et al. Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats[J]. 脑研究通报,2011.
APA	Han, Xiao,Wang, Weiwen,Xue, Xiaofang,Shao, Feng,&Li, Nanxin.(2011).Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats.脑研究通报.
MLA	Han, Xiao,et al."Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats".脑研究通报 (2011).