Perceived location specificity in perceptual separation-induced but not   fear conditioning-induced enhancement of prepulse inhibition in rats

doi:10.1016/j.bbr.2014.04.030

CORC > 北京大学 > 心理与认知科学学院

	Perceived location specificity in perceptual separation-induced but not fear conditioning-induced enhancement of prepulse inhibition in rats
	Lei, Ming ; Luo, Lu ; Qu, Tianshu ; Jia, Hongxiao ; Li, Liang
刊名	行为大脑研究
	2014
关键词	Prepulse inhibition Fear conditioning Precedence effect Perceptual spatial separation Perceived location specificity Metabotropic glutamate receptor ACOUSTIC STARTLE RESPONSE DEFICIENT ATTENTIONAL MODULATION ISOLATION-REARED RATS CHRONIC-SCHIZOPHRENIA NEURAL PLASTICITY LATERAL AMYGDALA SOCIAL-ISOLATION NOISE SOUNDS REFLEX EXTINCTION
DOI	10.1016/j.bbr.2014.04.030
英文摘要	Prepulse inhibition (PPI) is the suppression of the startle reflex when the startling stimulus is shortly preceded by a non-startling stimulus (the prepulse). Previous studies have shown that both fear conditioning of a prepulse and precedence-effect-induced perceptual separation between the conditioned prepulse and a noise masker facilitate selective attention to the prepulse and consequently enhance PPI with a remarkable prepulse-feature specificity. This study investigated whether the two types of attentional enhancements of PPI in rats also exhibit a prepulse-location specificity. The results showed that when a prepulse was delivered by each of the two spatially separated loudspeakers, fear conditioning of the prepulse at a particularly perceived location (left or right to the tested rat) enhanced PPI without exhibiting any perceived-location specificity. However, when a noise masker was presented, the precedence-effect-induced perceptual separation between the conditioned prepulse and the noise masker further enhanced PPI when the prepulse was perceived as coming from the location that was conditioned but not the location without being conditioned. Moreover, both conditioning-induced and perceptual separation-induced PPI enhancements were eliminated by extinction learning, whose effect could be blocked by systemic injection of the selective antagonist of metabotropic glutamate receptor subtype 5 (mGluR5), 2-methyl-6-(phenylethynyl)-pyridine (MPEP). Thus, fear conditioning of a prepulse perceived at a particular location not only facilitates selective attention to the conditioned prepulse but also induces a learning-based spatial gating effect on the spatial unmasking of the conditioned prepulse, leading to that the perceptual separation-induced PPI enhancement becomes perceived-location specific. (C) 2014 Elsevier B.V. All rights reserved.; Behavioral Sciences; Neurosciences; SCI(E); PubMed; 0; ARTICLE; liangli@pku.edu.cn; 87-94; 269
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162751]
专题	心理与认知科学学院信息科学技术学院
推荐引用方式 GB/T 7714	Lei, Ming,Luo, Lu,Qu, Tianshu,et al. Perceived location specificity in perceptual separation-induced but not fear conditioning-induced enhancement of prepulse inhibition in rats[J]. 行为大脑研究,2014.
APA	Lei, Ming,Luo, Lu,Qu, Tianshu,Jia, Hongxiao,&Li, Liang.(2014).Perceived location specificity in perceptual separation-induced but not fear conditioning-induced enhancement of prepulse inhibition in rats.行为大脑研究.
MLA	Lei, Ming,et al."Perceived location specificity in perceptual separation-induced but not fear conditioning-induced enhancement of prepulse inhibition in rats".行为大脑研究 (2014).