The different effects of maternal separation on spatial learning and   reversal learning in rats

doi:10.1016/j.bbr.2014.11.040

CORC > 北京大学 > 心理与认知科学学院

	The different effects of maternal separation on spatial learning and reversal learning in rats
	Wang, Qiong ; Li, Man ; Du, Wei ; Shao, Feng ; Wang, Weiwen
刊名	行为大脑研究
	2015
关键词	Maternal separation Locomotor activity Anxiety Spatial learning Reversal learning NEUROTROPHIC FACTOR EXPRESSION MORRIS WATER MAZE ADULT RATS SOCIAL-ISOLATION DORSOMEDIAL STRIATUM BEHAVIORAL-RESPONSES PREPULSE INHIBITION SYNAPTIC PLASTICITY PREFRONTAL CORTEX ANIMAL-MODELS
DOI	10.1016/j.bbr.2014.11.040
英文摘要	Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1 to 21) on locomotor activity and anxiety behavior in open field, spatial learning and reversal learning in Morris water maze of male and female juvenile (PND 21), adolescent (PND 35) and early adult (PND 56) Wistar rats. The results indicated that MS increased locomotor activity of rats across all ages and reduced anxiety behavior of adolescent rats in open field test. MS also increased swim distance in spatial learning and decreased escape latency in reversal learning in adolescent and early adult rats. Additionally, for socially reared rats, there was increased spontaneous locomotion with age, decreased reversal learning ability with age. The present study provides novel insights into the consequences of MS and demonstrates unique age-dependent changes at the behavioral levels. (C) 2014 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348255400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Behavioral Sciences; Neurosciences; SCI(E); PubMed; 2; ARTICLE; shaof@pku.edu.cn; wangww@psych.ac.cn; 16-23; 280
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162727]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Wang, Qiong,Li, Man,Du, Wei,et al. The different effects of maternal separation on spatial learning and reversal learning in rats[J]. 行为大脑研究,2015.
APA	Wang, Qiong,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2015).The different effects of maternal separation on spatial learning and reversal learning in rats.行为大脑研究.
MLA	Wang, Qiong,et al."The different effects of maternal separation on spatial learning and reversal learning in rats".行为大脑研究 (2015).