Psammoma bodies in two types of human ovarian tumours: a mineralogical   study (vol 109, pg 357, 2015)

doi:10.1007/s00710-015-0381-7

CORC > 北京大学 > 地球与空间科学学院

	Psammoma bodies in two types of human ovarian tumours: a mineralogical study (vol 109, pg 357, 2015)
	Meng, Fanlu ; Wang, Changqiu ; Li, Yan ; Lu, Anhuai ; Mei, Fang ; Liu, Jianying ; Du, Jingyun ; Zhang, Yan
刊名	MINERALOGY AND PETROLOGY
	2015
关键词	CANCER COLLAGEN NANOBACTERIA NUCLEATION CRYSTAL SITES BODY
DOI	10.1007/s00710-015-0381-7
英文摘要	Psammoma body (PB) is a common form of calcification in pathological diagnosis and closely relevant to tumours. This paper focuses on the mineralogical characteristics of PBs in ovarian serous cancer and teratoma by using polarization microscope (POM), environmental scanning electron microscope (ESEM), micro-Fourier transform infrared spectroscopy (micro-FT-IR), transmission electron microscope (TEM), micro-area synchrotron radiation X-ray powder diffraction (mu-SRXRD) and fluorescence (mu-SRXRF). Both the PBs in tissues and separated from eight typical cases were investigated. POM and ESEM observation revealed the inside-out growth pattern of PBs. mu-SRXRD and micro-FT-IR results demonstrated the dominant mineral phase of PBs in ovarian serous cancer and teratoma was AB-type carbonate hydroxyapatite (Ca-10[(PO4)(6-x-y)(CO3)(x)(HPO4)(y)][(OH)(2-u)(CO3)(u)] with 0 a parts per thousand currency signaEuro parts per thousand x,y,u a parts per thousand currency signaEuro parts per thousand 2). As observed by ESEM and TEM, the layer-rich PBs in teratoma were up to 70 mu m and mainly consisted of 5 nm-wide, 5-12 nm-long columnar crystals; the PBs in ovarian serous cancer with a maximum diameter of 35 mu m were composed of slightly longer columnar crystals and granulates with 20-100 nm in diameter. The selected area electron diffraction patterns showed dispersed polycrystalline diffraction rings with arching behavior of (002) diffraction, indicating the aggregated nanocrystals grew in the preferred orientation of (002) face. The EDX and mu-SRXRF results together indicated the existence of Na, Mg, Zn and Sr in PBs. These detailed mineralogical characteristics may help uncover the nature of the pathological PBs in ovary.; SCI(E); CORRECTION; ahlu@pku.edu.cn; liyan-pku@pku.edu.cn; 3; 367-375; 109
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419744]
专题	地球与空间科学学院
推荐引用方式 GB/T 7714	Meng, Fanlu,Wang, Changqiu,Li, Yan,et al. Psammoma bodies in two types of human ovarian tumours: a mineralogical study (vol 109, pg 357, 2015)[J]. MINERALOGY AND PETROLOGY,2015.
APA	Meng, Fanlu.,Wang, Changqiu.,Li, Yan.,Lu, Anhuai.,Mei, Fang.,...&Zhang, Yan.(2015).Psammoma bodies in two types of human ovarian tumours: a mineralogical study (vol 109, pg 357, 2015).MINERALOGY AND PETROLOGY.
MLA	Meng, Fanlu,et al."Psammoma bodies in two types of human ovarian tumours: a mineralogical study (vol 109, pg 357, 2015)".MINERALOGY AND PETROLOGY (2015).