Properties and cellular effects of particulate matter from direct   emissions and ambient sources

doi:10.1080/10934529.2016.1198632

CORC > 北京大学 > 城市与环境学院

	Properties and cellular effects of particulate matter from direct emissions and ambient sources
	Jin, Wenjie ; Su, Shu ; Wang, Bin ; Zhu, Xi ; Chen, Yilin ; Shen, Guofeng ; Liu, Junfeng ; Cheng, Hefa ; Wang, Xilong ; Wu, Shuiping ; Zeng, Eddy ; Xing, Baoshan ; Tao, Shu
刊名	JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
	2016
关键词	in vitro toxicity test particulate matter physicochemical properties ROS TNF- POLYCYCLIC AROMATIC-HYDROCARBONS LONG-RANGE TRANSPORT OXIDATIVE STRESS EPITHELIAL-CELLS AIR-POLLUTION MEXICO-CITY RURAL CHINA IN-VITRO SIZE COMBUSTION
DOI	10.1080/10934529.2016.1198632
英文摘要	The pollution of particulate matter (PM) is of great concern in China and many other developing countries. It is generally recognized that the toxicity of PM is source and property dependent. However, the relationship between PM properties and toxicity is still not well understood. In this study, PM samples from direct emissions of wood, straw, coal, diesel combustion, cigarette smoking and ambient air were collected and characterized for their physicochemical properties. Their expression of intracellular reactive oxygen species (ROS) and levels of inflammatory cytokines (i.e., tumor necrosis factor- (TNF-)) was measured using a RAW264.7 cell model. Our results demonstrated that the properties of the samples from different origins exhibited remarkable differences. Significant increases in ROS were observed when the cells were exposed to PMs from biomass origins, including wood, straw and cigarettes, while increases in TNF- were found for all the samples, particularly those from ambient air. The most important factor associated with ROS generation was the presence of water-soluble organic carbon, which was extremely abundant in the samples that directly resulted from biomass combustion. Metals, endotoxins and PM size were the most important properties associated with increases in TNF- expression levels. The association of the origins of PM particles and physicochemical properties with cytotoxic properties is illustrated using a cluster analysis.; National Natural Science Foundation of China [41390240, 41130754, 41301554, 41328003]; SCI(E); EI; PubMed; ARTICLE; taos@pku.edu.cn; 12; 1075-1083; 51
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493498]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Jin, Wenjie,Su, Shu,Wang, Bin,et al. Properties and cellular effects of particulate matter from direct emissions and ambient sources[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING,2016.
APA	Jin, Wenjie.,Su, Shu.,Wang, Bin.,Zhu, Xi.,Chen, Yilin.,...&Tao, Shu.(2016).Properties and cellular effects of particulate matter from direct emissions and ambient sources.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING.
MLA	Jin, Wenjie,et al."Properties and cellular effects of particulate matter from direct emissions and ambient sources".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING (2016).