Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA):   Chemical synthesis and correlation between their urinary levels and   plasma TBBPA content in voluntary human donors

doi:10.1016/j.envint.2016.09.018

CORC > 北京大学 > 城市与环境学院

	Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors
	Ho, Ka-Lok ; Yuen, Ka-Ki ; Yau, Man-Shan ; Murphy, Margaret B. ; Wan, Yi ; Fong, Bonnie M.W. ; Tam, Sidney ; Giesy, John P. ; Leung, Kelvin S.Y. ; Lam, Michael H.W.
刊名	ENVIRONMENT INTERNATIONAL
	2017
关键词	Tetrabromobisphenol-A Glucuronide and sulfate conjugates Body fluids Human plasma Human urine BROMINATED FLAME RETARDANTS POLYBROMINATED DIPHENYL ETHERS ENANTIOMER-SPECIFIC DISTRIBUTION PEARL RIVER DELTA BREAST-MILK BISPHENOL-A SOUTH CHINA ORGANOHALOGEN CONTAMINANTS EXPOSURE ASSESSMENT DIETARY EXPOSURE
DOI	10.1016/j.envint.2016.09.018
英文摘要	3,3', 5,5'-Tetrabromobisphenol-A (TBBPA) is an important brominated flame retardant in epoxy, vinyl esters and polycarbonate resins. Previous studies have already shown the occurrence of its Phase II metabolites, TBBPA-glucuronide and sulfate conjugates, in human urine, after oral administration of TBBPA. The main objective of this work is to examine correlations among level of TBBPA in human blood and those of its Phase II metabolites in human urine. Four water-soluble TBBPA conjugates were synthesized, purified and characterized. An analytical protocol using solid-phase extraction and liquid chromatography-electrospray tandem mass spectrometry (SPE-LC-MS/MS) quantification was developed for the simultaneous analysis of these glucuronide and sulfate conjugates in human urine samples. TBBPA and its Phase II metabolites in paired human plasma and urine samples collected randomly from 140 voluntary donors in Hong Kong SAR, China, were determined. One or more TBBPA conjugates were detected in all of the urine samples, with concentration ranging from 0.19 to 127.24 mu g g(-1)-creatinine. TBBPA was also quantified in >85% of the plasma and urine samples. Strong correlations were observed between TBBPA content in plasma and the total amount of TBBPA-related compounds in urine. (C) 2016 Elsevier Ltd. All rights reserved.; State Key Laboratory for Marine Pollution, City University of Hong Kong; Research Grants Council of the Hong Kong Special Administrative Region, China [CityU 160513]; program of "Great Concentration Foreign Experts" - State Administration of Foreign Experts Affairs, the P.R. China [GDW20123200120]; Einstein Professor Program of the Chinese Academy of Sciences; Canada Research Chair program, a Visiting Distinguished Professorship in the Department of Biology and Chemistry; State Key Laboratory in Marine Pollution, City University of Hong Kong; SCI(E); ARTICLE; 46-53; 98
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/476523]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Ho, Ka-Lok,Yuen, Ka-Ki,Yau, Man-Shan,et al. Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors[J]. ENVIRONMENT INTERNATIONAL,2017.
APA	Ho, Ka-Lok.,Yuen, Ka-Ki.,Yau, Man-Shan.,Murphy, Margaret B..,Wan, Yi.,...&Lam, Michael H.W..(2017).Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors.ENVIRONMENT INTERNATIONAL.
MLA	Ho, Ka-Lok,et al."Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors".ENVIRONMENT INTERNATIONAL (2017).