Toxicity of triphenyltin on the development of retinal axons in   zebrafish at low dose

doi:10.1016/j.aquatox.2017.05.009

CORC > 北京大学 > 城市与环境学院

	Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose
	Xiao, Yue ; Jiang, Jieqiong ; Hu, Wenxin ; Zhao, Yanbin ; Hu, Jianying
刊名	AQUATIC TOXICOLOGY
	2017
关键词	Retinal ganglion cell axons Dark pigmentation Retinoic acid Vision defect Teratogenicity MEDAKA ORYZIAS-LATIPES XENOPUS-LAEVIS TROPHIC MAGNIFICATION ORGANOTIN COMPOUNDS MELATONIN RHYTHMS LIMB DEVELOPMENT NERVOUS-SYSTEM GANGLION-CELL X-RECEPTOR VITAMIN-A
DOI	10.1016/j.aquatox.2017.05.009
英文摘要	The impacts of triphenyltin (TPT) on ecological health are of particular concern due to the unexpectedly high levels found in wild fish around the world. Here, zebrafish embryos were exposed to TPT via in ovo nano injection to study its toxicity on the development of retinal axons in fish. Lipophilic dye labeling revealed obvious defects in retinal axon development in larvae with normally shaped eyes, with incidences of 0, 1.08%, 2.66%, 4.26%, and 6.85% observed in the control, 0.8, 4.0, 20.0, and 100 ng TPT-Cl/g wet weight (ww) exposure groups, respectively, showing a dose-dependent increase. Since the lowest observable effective concentration of TPT to induce retinal axon development defects was 0.8 ng TPT-Cl/g ww, which is lower than the concentrations in wild fish eggs, this defect would occur in wild fish larvae. Alterations in the expressions of pax6 and ephrinBs, which regulate the establishment of retinal polarity, were correlated with defect incidence. Expression levels of the CYP26A1 gene and protein were significantly up-regulated in all exposure groups compared with the control, which may lead to significant decreases in concentrations of all trans retinoic acid (atRA). Such a disruption of RA metabolism would, at least partly, contribute to the incidence of developmental defects in retinal axons. This study is the first to report that TPT can interfere with development of retinal axons in fish at low dose.; National Natural Science Foundation of China [41330637]; International S & T Cooperation Program of China [2016YFE0117800]; SCI(E); ARTICLE; 9-15; 189
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/471870]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Xiao, Yue,Jiang, Jieqiong,Hu, Wenxin,et al. Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose[J]. AQUATIC TOXICOLOGY,2017.
APA	Xiao, Yue,Jiang, Jieqiong,Hu, Wenxin,Zhao, Yanbin,&Hu, Jianying.(2017).Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose.AQUATIC TOXICOLOGY.
MLA	Xiao, Yue,et al."Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose".AQUATIC TOXICOLOGY (2017).