Intrinsic Clearance of Xenobiotic Chemicals by Liver Microsomes:   Assessment of Trophic Magnification Potentials

doi:10.1021/acs.est.6b01178

CORC > 北京大学 > 城市与环境学院

	Intrinsic Clearance of Xenobiotic Chemicals by Liver Microsomes: Assessment of Trophic Magnification Potentials
	Zheng Guomao ; Wan Yi ; Hu Jianying
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2016
关键词	MARINE FOOD-WEB POLYBROMINATED DIPHENYL ETHERS PERSISTENT ORGANIC POLLUTANTS TROUT ONCORHYNCHUS-MYKISS POLYCYCLIC AROMATIC-HYDROCARBONS VITRO BIOTRANSFORMATION RATES WATER PARTITION-COEFFICIENTS NORTH CHINA RAINBOW-TROUT BOHAI BAY
DOI	10.1021/acs.est.6b01178
英文摘要	The use of trophic magnification factors (TMFs) to characterize the bioaccumulation potentials of chemicals was encouraged; however, the method for the assessment of trophic magnification potentials is still lacking. We optimized the in vitro assays used for the measurement of intrinsic clearance in liver microsomes by incorporating benzo[a]pyrene (B(a)P) as a benchmark compound. The intrinsic clearance of 40 compounds was then measured in microsomes from fish (weevers) and birds (quail); the characteristics of the trophic transfer of these 40 compounds were previously investigated in an aquatic food web in Bohai in northern China. Chemicals that are biotransformed at a rate similar to or higher than that of B[a]P in the microsomes of both weevers and quail (in vitro intrinsic clearance values, CL; CL/CLB[a]P: 0.1 to 2.4) generally exhibited no significant trophic magnification or dilution in the food web (TMF approximate to 1 or < 1), whereas chemicals that are biotransformed at extremely slow rates compared with B[a]P (CL/CLB[a]P: 0 to 0.2) showed significant trophic magnification in the food web (TMF > 1). The in vitro intrinsic clearance values of the target chemicals were found to be consistent with their respective trophic transfer behavior in the aquatic food web. Significant negative correlations were also found between the TMFs and the intrinsic clearance values of all target chemicals obtained in microsomes from both weevers and quail. Multiple linear regression analysis showed that biotransformation rates (CL/CLB[a]P) are a more important factor compared with the lipophilicity of the chemicals (log K-ow) in the assessment of the trophic magnification of chemicals in the aquatic food web.; National Natural Science Foundation of China [41330637, 21422701]; Special Scientific Research Funds for Environmental Protection Commonweal Section [201309027]; National Basic Research Program of China [2015CB458900]; SCI(E); EI; PubMed; ARTICLE; wany@urban.pku.edu; 12; 6343-6353; 50
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433834]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Zheng Guomao,Wan Yi,Hu Jianying. Intrinsic Clearance of Xenobiotic Chemicals by Liver Microsomes: Assessment of Trophic Magnification Potentials[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2016.
APA	Zheng Guomao,Wan Yi,&Hu Jianying.(2016).Intrinsic Clearance of Xenobiotic Chemicals by Liver Microsomes: Assessment of Trophic Magnification Potentials.ENVIRONMENTAL SCIENCE & TECHNOLOGY.
MLA	Zheng Guomao,et al."Intrinsic Clearance of Xenobiotic Chemicals by Liver Microsomes: Assessment of Trophic Magnification Potentials".ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016).