Reproductive Inhibition and Transgenerational Toxicity of Triphenyltin   on Medaka (Oryzias latipes) at Environmentally Relevant tip Levels

doi:10.1021/es801573x

CORC > 北京大学 > 城市与环境学院

	Reproductive Inhibition and Transgenerational Toxicity of Triphenyltin on Medaka (Oryzias latipes) at Environmentally Relevant tip Levels
	Zhang, Zhaobin ; Hu, Jianying ; Zhen, Huajun ; Wu, Xiaoqin ; Huang, Chong
刊名	environmental science technology
	2008
关键词	ENDOCRINE DISRUPTING CHEMICALS ZEBRAFISH DANIO-RERIO EARLY-LIFE STAGES MARINE FOOD-WEB ORGANOTIN ACCUMULATION 11-BETA-HYDROXYSTEROID DEHYDROGENASE PIMEPHALES-PROMELAS RETINOIC ACID FRESH-WATERS FISH
DOI	10.1021/es801573x
英文摘要	An increasing number of studies have reported unexpectedly high body burdens of triphenyltin (TPT) in wild fishes around the world. To assess the effects of TPT on fish, we exposed pairs of medaka (Oryzias latipes) to different levels of TPT for 5 weeks, and the reproduction responses and transgenerational effects were studied. The results demonstrated that TPT exposure markedly suppressed the spawning frequency, spawned egg number, egg quality and gonad development and induced teratogenesis, such as hemorrhaging, eye defects, morphological malformation and conjoined twins, less hatchability, and swimup failure in the F1 generation, thereby resulting in a significant decrease in the capacity to produce viable offspring (p < 0.01). The residual TPT levels in the exposure fish are in the range of 6.52 +/- 0.56 to 5595 +/- 1016 ng of TPT/g of wet weight, similar to those reported in wild fish around the world, indicating TPT contamination in the real world would have a significant adverse effect on the health of fish population. Down-regulation of vitellogenin (VrG) genes in the female of the TPT exposure groups was recognized as a cause for the decreased fecundity. Expressions of VEGFs and PAX6 associated with vascular or ocular development, respectively, were measured in hemorrhaging and eye defects embryos and showed good correlations with response outcomes.; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 34; ARTICLE; 21; 8133-8139; 42
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160736]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Zhang, Zhaobin,Hu, Jianying,Zhen, Huajun,et al. Reproductive Inhibition and Transgenerational Toxicity of Triphenyltin on Medaka (Oryzias latipes) at Environmentally Relevant tip Levels[J]. environmental science technology,2008.
APA	Zhang, Zhaobin,Hu, Jianying,Zhen, Huajun,Wu, Xiaoqin,&Huang, Chong.(2008).Reproductive Inhibition and Transgenerational Toxicity of Triphenyltin on Medaka (Oryzias latipes) at Environmentally Relevant tip Levels.environmental science technology.
MLA	Zhang, Zhaobin,et al."Reproductive Inhibition and Transgenerational Toxicity of Triphenyltin on Medaka (Oryzias latipes) at Environmentally Relevant tip Levels".environmental science technology (2008).