Recent advances in the research for the homolog of breast cancer   associated gene AtROW1 in higher plants

doi:10.1007/s11427-016-5086-6

CORC > 北京大学 > 生命科学学院

	Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants
	Jiao, Yue ; Zhang, Yuzhou ; Zhu, Yu-Xian
刊名	SCIENCE CHINA-LIFE SCIENCES
	2016
关键词	repressor of Wuschel-1 DNA repair stem cell niche STEM-CELL NICHES ARABIDOPSIS-THALIANA PHD FINGER TRANSPOSABLE ELEMENTS TUMOR-SUPPRESSOR DNA-REPAIR BRCA1/BARD1 HETERODIMER APICAL MERISTEM BRCA1 RECOMBINATION
DOI	10.1007/s11427-016-5086-6
英文摘要	BARD1 (BRCA1 associated RING domain protein 1), as an important animal tumor suppressor gene associated with many kinds of cancers, has been intensively studied for decades. Surprisingly, homolog of BARD1 was found in plants and it was renamed AtROW1 (repressor of Wuschel-1) according to its extremely important function with regard to plant stem cell homeostasis. Although great advances have been made in human BARD1, the function of this animal tumor-suppressor like gene in plant is not well studied and need to be further elucidated. Here, we review and summarize past and present work regarding this protein. Apart from its previously proposed role in DNA repair, recently it is found essential for shoot and root stem cell development and differentiation in plants. The study of AtROW1 in plant may provide an ideal model for further elucidating the functional mechanism of BARD1 in mammals.; National Natural Science Foundation of China [90717009]; SCI(E); PubMed; 中国科学引文数据库(CSCD); REVIEW; zhuyx2@pku.edu.cn; 8; 825-831; 59
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/491711]
专题	生命科学学院
推荐引用方式 GB/T 7714	Jiao, Yue,Zhang, Yuzhou,Zhu, Yu-Xian. Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants[J]. SCIENCE CHINA-LIFE SCIENCES,2016.
APA	Jiao, Yue,Zhang, Yuzhou,&Zhu, Yu-Xian.(2016).Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants.SCIENCE CHINA-LIFE SCIENCES.
MLA	Jiao, Yue,et al."Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants".SCIENCE CHINA-LIFE SCIENCES (2016).