hCINAP negatively regulates NF-kappa B signaling by recruiting the   phosphatase PP1 to deactivate IKK complex

doi:10.1093/jmcb/mjv041

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	hCINAP negatively regulates NF-kappa B signaling by recruiting the phosphatase PP1 to deactivate IKK complex
	Qu, Linglong ; Ji, Yapeng ; Zhu, Xi ; Zheng, Xiaofeng
刊名	JOURNAL OF MOLECULAR CELL BIOLOGY
	2015
关键词	hCINAP NF-kappa B IKK complex phosphatase PP1 inflammatory diseases KINASE COMPLEX PROTEIN PHOSPHATASE-1 INFLAMMATORY DISEASES RHEUMATOID-ARTHRITIS ADENYLATE KINASE ACTIVATION PHOSPHORYLATION 2A UBIQUITINATION SPECIFICITY
DOI	10.1093/jmcb/mjv041
英文摘要	Tight regulation of nuclear factor-kappa B (NF-kappa B) signaling is essential to maintain homeostasis in immune system in response to various stimuli, which hasbeen studied extensivelyand deeply. However, the molecularmechanisms responsible for its negative regulation are not completely understood. Here we demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappa B signaling by deactivating IkB kinase (IKK) complex. In response to TNF stimulation, hCINAP dynamically associates with IKK alpha and IKK beta and inhibits IKK phosphorylation. Notably, hCINAP directly interacts with the catalytic subunits of protein phosphatase 1 (PP1) and mediates the formation of IKK-hCINAP-PP1 complex, serving as an adaptor protein that recruits PP1 to dephosphorylate IKK. Furthermore, decreased levels of hCINAP are observed in several inflammatory diseases with NF-kappa B hyperactivity. Our study suggests a novel mechanism underlying deactivation of IKK and provides new insight into the negative regulation of NF-kappa B signaling.; supported by the National Science Foundation of China,the Seeding Grant for Medicine and Life Sciences of Peking University,the Doctoral Fund of Ministry of Education of China; SCI(E); PubMed; 中国科学引文数据库(CSCD); ARTICLE; xiaofengz@pku.edu.cn; 6; 529-542; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/491474]
专题	生命科学学院
推荐引用方式 GB/T 7714	Qu, Linglong,Ji, Yapeng,Zhu, Xi,et al. hCINAP negatively regulates NF-kappa B signaling by recruiting the phosphatase PP1 to deactivate IKK complex[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2015.
APA	Qu, Linglong,Ji, Yapeng,Zhu, Xi,&Zheng, Xiaofeng.(2015).hCINAP negatively regulates NF-kappa B signaling by recruiting the phosphatase PP1 to deactivate IKK complex.JOURNAL OF MOLECULAR CELL BIOLOGY.
MLA	Qu, Linglong,et al."hCINAP negatively regulates NF-kappa B signaling by recruiting the phosphatase PP1 to deactivate IKK complex".JOURNAL OF MOLECULAR CELL BIOLOGY (2015).