Recipient-donor KIR ligand matching prevents CMV reactivation   post-haploidentical T cell-replete transplantation

doi:10.1111/bjh.14622

CORC > 北京大学 > 生命科学学院

	Recipient-donor KIR ligand matching prevents CMV reactivation post-haploidentical T cell-replete transplantation
	Zhao, Xiang-Yu ; Luo, Xue-Yi ; Yu, Xing-Xing ; Zhao, Xiao-Su ; Han, Ting-Ting ; Chang, Ying-Jun ; Huo, Ming-Rui ; Xu, Lan-Ping ; Zhang, Xiao-Hui ; Liu, Kai-Yan ; Li, Dan ; Jiang, Zheng-Fan ; Huang, Xiao-Jun
刊名	BRITISH JOURNAL OF HAEMATOLOGY
	2017
关键词	KIR haploidentical HSCT CMV NATURAL-KILLER-CELLS ACUTE MYELOID-LEUKEMIA MHC CLASS-I CYTOMEGALOVIRUS-INFECTION NK CELLS MARROW TRANSPLANTATION CORD BLOOD HLA RECEPTOR RELAPSE
DOI	10.1111/bjh.14622
英文摘要	Licensed natural killer (NK) cells have been demonstrated to have anti-cytomegalovirus (CMV) activity. We prospectively analysed the human leucocyte antigen typing of donor-recipient pairs and the killer cell immunoglobulin-like receptor (KIR) typing of donors for 180 leukaemia patients to assess the predictive roles of licensed NK cells on CMV reactivation post-T-cell-replete haploidentical stem cell transplantation. Multivariate analysis showed that donor-recipient KIR ligand graft-versus-host or host-versus-graft direction mismatch was associated with increased refractory CMV infection (Hazard ratio = 2.556, 95% confidence interval, 1.377-4.744, P = 0.003) post-transplantation. Donor-recipient KIR ligand matching decreased CMV reactivation [51.65% (46.67, 56.62%) vs. 75.28% (70.87, 79.69%), P = 0.012], refractory CMV infection [17.58% (13.77, 21.40%) vs. 35.96% (31.09, 40.82%), P = 0.004] and CMV disease [3.30% (1.51, 5.08%) vs. 11.24% (8.04, 14.43%), P = 0.024] by day 100 post-transplantation. In addition, the percentage of c-interferon expression on donor-derived NK cells was significantly higher in the recipients among the recipient-donor pairs with a KIR ligand match compared with that in the recipients among the pairs with a KIR ligand graft-versus-host or host-versus- graft direction mismatch on days 30 and 100 post-transplantation (P = 0.036 and 0.047, respectively). These findings have suggested that donor-recipient KIR ligand matching might promote the NK cell licensing process, thereby increasing NK cell-mediated protection against CMV reactivation.; National Natural Science Foundation of China [81670166, 81530046, 81270644, 81230013]; Major State Basic Research Development Program of China (973 Program) [2013CB733700]; Beijing Talents Fund [2015000021223ZK26]; Milstein Medical Asian American Partnership (MMAAP) Foundation; Collaborative Innovation Centre of Haematology, Peking University, China; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81621001]; SCI(E); ARTICLE; 5; 766-781; 177
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473150]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, Xiang-Yu,Luo, Xue-Yi,Yu, Xing-Xing,et al. Recipient-donor KIR ligand matching prevents CMV reactivation post-haploidentical T cell-replete transplantation[J]. BRITISH JOURNAL OF HAEMATOLOGY,2017.
APA	Zhao, Xiang-Yu.,Luo, Xue-Yi.,Yu, Xing-Xing.,Zhao, Xiao-Su.,Han, Ting-Ting.,...&Huang, Xiao-Jun.(2017).Recipient-donor KIR ligand matching prevents CMV reactivation post-haploidentical T cell-replete transplantation.BRITISH JOURNAL OF HAEMATOLOGY.
MLA	Zhao, Xiang-Yu,et al."Recipient-donor KIR ligand matching prevents CMV reactivation post-haploidentical T cell-replete transplantation".BRITISH JOURNAL OF HAEMATOLOGY (2017).