Apical constriction is driven by a pulsatile apical myosin network in   delaminating Drosophila neuroblasts

doi:10.1242/dev.150763

CORC > 北京大学 > 生命科学学院

	Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts
	An, Yanru ; Xue, Guosheng ; Yang Shaobo ; Deng Mingxi ; Zhou, Xiaowei ; Yu, Weichuan ; Ishibashi, Toyotaka ; Zhang, Lei ; Yan, Yan
刊名	DEVELOPMENT
	2017
关键词	Apical constriction Drosophila neuroblast Myosin TISSUE MORPHOGENESIS EPITHELIAL MORPHOGENESIS CYTOSKELETAL DYNAMICS CELL INTERCALATION TUBE FORMATION MECHANISM MELANOGASTER CONTRACTIONS INTEGRATION ACTIVATION
DOI	10.1242/dev.150763
英文摘要	Cell delamination is a conserved morphogenetic process important for the generation of cell diversity and maintenance of tissue homeostasis. Here, we used Drosophila embryonic neuroblasts as a model to study the apical constriction process during cell delamination. We observe dynamic myosin signals both around the cell adherens junctions and underneath the cell apical surface in the neuroectoderm. On the cell apical cortex, the nonjunctional myosin forms flows and pulses, which are termed medial myosin pulses. Quantitative differences in medial myosin pulse intensity and frequency are crucial to distinguish delaminating neuroblasts from their neighbors. Inhibition of medial myosin pulses blocks delamination. The fate of a neuroblast is set apart from that of its neighbors by Notch signaling-mediated lateral inhibition. When we inhibit Notch signaling activity in the embryo, we observe that small clusters of cells undergo apical constriction and display an abnormal apical myosin pattern. Together, these results demonstrate that a contractile actomyosin network across the apical cell surface is organized to drive apical constriction in delaminating neuroblasts.; Research Grants Council, University Grants Committee of the Hong Kong Special Administrative Region [GRF16103815, 16103314, 16150016, AoE/M-09/12, ITC-CNERC14SC01, GRF16150216, ECS26100214]; National Natural Science Foundation of China [11622102, 91430217]; SCI(E); ARTICLE; 12; 2153-2164; 144
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472779]
专题	生命科学学院
推荐引用方式 GB/T 7714	An, Yanru,Xue, Guosheng,Yang Shaobo,et al. Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts[J]. DEVELOPMENT,2017.
APA	An, Yanru.,Xue, Guosheng.,Yang Shaobo.,Deng Mingxi.,Zhou, Xiaowei.,...&Yan, Yan.(2017).Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts.DEVELOPMENT.
MLA	An, Yanru,et al."Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts".DEVELOPMENT (2017).