Optogenetic activation of dorsal raphe neurons rescues the autistic-like   social deficits in Shank3 knockout mice

doi:10.1038/cr.2017.52

CORC > 北京大学 > 生命科学学院

	Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice
	Luo, Junyu ; Feng, Qiru ; Wei, Liping ; Luo, Minmin
刊名	CELL RESEARCH
	2017
关键词	SPECTRUM DISORDER REWARD DOPAMINE BEHAVIOR
DOI	10.1038/cr.2017.52
英文摘要	Impaired social interaction is one of the core symptoms of the autism spectrum disorder (ASD) [1]. However, the etiology and neural circuit mechanisms underlying these behavioral impairments are not well understood [2]. Currently, behavioral therapies are the most effective interventions for ASD, although the benefits from such treatments are minimal [3, 4]. Here, we demonstrate that the autistic-like social deficits of Shank3 knockout mice [5] can be durably rescued by social training coupled with optogenetic activation of neurons in the midbrain dorsal raphe nucleus (DRN) — a region encoding reward through 5-HT and glutamate [6]. A single training session resulted in a significant rescue effect on social preference, and such rescue effect was retained for several days with increased neuronal activation in the DRN when facing social stimuli. Multiple training sessions resulted in much longer-lasting rescue effects. Intriguingly, the durable rescue effect was generated by stimulating Pet-1 neurons in the DRN, but not by stimulating dopamine neurons in the ventral tegmental area (VTA)——the classical reward center. Our results suggest that the DRN should be viewed as an attractive target for future ASD interventions.; Ministry of Science and Technology of China [2012YQ03026005, 2013ZX0950910, 2015BAI08B02]; National Natural Science Foundation of China [91432114, 91632302]; Beijing Municipal Government; SCI(E); 中国科学引文数据库(CSCD); LETTER; 7; 950-953; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472467]
专题	生命科学学院
推荐引用方式 GB/T 7714	Luo, Junyu,Feng, Qiru,Wei, Liping,et al. Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice[J]. CELL RESEARCH,2017.
APA	Luo, Junyu,Feng, Qiru,Wei, Liping,&Luo, Minmin.(2017).Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice.CELL RESEARCH.
MLA	Luo, Junyu,et al."Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice".CELL RESEARCH (2017).