Genomic signatures of pancreatic adenosquamous carcinoma (PASC)

doi:10.1002/path.4943

CORC > 北京大学 > 生命科学学院

	Genomic signatures of pancreatic adenosquamous carcinoma (PASC)
	Fang, Yuan ; Su, Zhe ; Xie, Jing ; Xue, Ruidong ; Ma, Qi ; Li, Yanmeng ; Zhao, Yifan ; Song, Zeshi ; Lu, Xiongxiong ; Li, Hongwei ; Peng, Chenghong ; Bai, Fan ; Shen, Baiyong
刊名	JOURNAL OF PATHOLOGY
	2017
关键词	pancreatic adenosquamous carcinoma (PASC) mixed cancer TP53 3p loss CANCER ABERRATIONS STATISTICS
DOI	10.1002/path.4943
英文摘要	In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents similar to 4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas. Copyright (C) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.; Science & Technology Commission of Shanghai [15JC1402800, 14XD1402800]; Shanghai Eastern Youth Scholar Programme; National High Technology Research and Development Programme of China (863 Programme) [2015AA020403]; National Key Research and Development Programme [2016YFC0900100]; Beijing Municipal Science and Technology Commission [Z141100000214013]; Recruitment Programme of Global Youth Experts; SCI(E); ARTICLE; 2; 155-159; 243
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/470653]
专题	生命科学学院
推荐引用方式 GB/T 7714	Fang, Yuan,Su, Zhe,Xie, Jing,et al. Genomic signatures of pancreatic adenosquamous carcinoma (PASC)[J]. JOURNAL OF PATHOLOGY,2017.
APA	Fang, Yuan.,Su, Zhe.,Xie, Jing.,Xue, Ruidong.,Ma, Qi.,...&Shen, Baiyong.(2017).Genomic signatures of pancreatic adenosquamous carcinoma (PASC).JOURNAL OF PATHOLOGY.
MLA	Fang, Yuan,et al."Genomic signatures of pancreatic adenosquamous carcinoma (PASC)".JOURNAL OF PATHOLOGY (2017).