Activation and Functional Connectivity of the Left Inferior Temporal   Gyrus during Visual Speech Priming in Healthy Listeners and Listeners   with Schizophrenia

doi:10.3389/fnins.2017.00107

CORC > 北京大学 > 生命科学学院

	Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia
	Wu, Chao ; Zheng, Yingjun ; Li, Juanhua ; Zhang, Bei ; Li, Ruikeng ; Wu, Haibo ; She, Shenglin ; Liu, Sha ; Peng, Hongjun ; Ning, Yuping ; Li, Liang
刊名	FRONTIERS IN NEUROSCIENCE
	2017
关键词	speech recognition cocktail-party problem lipreading visual speech priming informational masking unmasking schizophrenia inferior temporal gyrus PRESENTED LIPREADING CUES HUMAN AUDITORY-CORTEX INFORMATIONAL MASKING WORKING-MEMORY AUDIOVISUAL SPEECH NEURAL BASIS MULTISENSORY INTEGRATION PREFRONTAL CORTEX SPOKEN SENTENCES BRAIN ACTIVATION
DOI	10.3389/fnins.2017.00107
英文摘要	Under a "cocktail-party" listening condition with multiple-people talking, compared to healthy people, people with schizophrenia benefit less from the use of visual-speech (lipreading) priming (VSP) cues to improve speech recognition. The neural mechanisms underlying the unmasking effect of VSP remain unknown. This study investigated the brain substrates underlying the unmasking effect of VSP in healthy listeners and the schizophrenia-induced changes in the brain substrates. Using functional magnetic resonance imaging, brain activation and functional connectivity for the contrasts of the VSP listening condition vs. the visual non-speech priming (VNSP) condition were examined in 16 healthy listeners (27.4 +/- 8.6 years old, 9 females and 7 males) and 22 listeners with schizophrenia (29.0 +/- 8.1 years old, 8 females and 14 males). The results showed that in healthy listeners, but not listeners with schizophrenia, the VSP-induced activation (against the VNSP condition) of the left posterior inferior temporal gyrus (pITG) was significantly correlated with the VSP-induced improvement in target-speech recognition against speech masking. Compared to healthy listeners, listeners with schizophrenia showed significantly lower VSP-induced activation of the left pITG and reduced functional connectivity of the left pITG with the bilateral Rolandic operculum, bilateral STG, and left insular. Thus, the left pITG and its functional connectivity may be the brain substrates related to the unmasking effect of VSP, assumedly through enhancing both the processing of target visual-speech signals and the inhibition of masking-speech signals. In people with schizophrenia, the reduced unmasking effect of VSP on speech recognition may be associated with a schizophrenia-related reduction of VSP-induced activation and functional connectivity of the left pITG.; "973" National Basic Research Program of China [2015CB351800]; National Natural Science Foundation of China [81671334, 81601168]; Beijing Municipal Science and Tech Commission [Z161100002616017]; Planed Science and Technology Projects of Guangzhou [2014Y2-00105]; Guangzhou Municipal Key Discipline in Medicine for Guangzhou Brain Hospital [GBH2014-ZD06, GBH2014-QN04]; Chinese National Key Clinical Program in Psychiatry to Guangzhou Brain Hospital [201201004]; China Postdoctoral Science Foundation General Program [2013M530453]; SCI(E); SSCI; ARTICLE; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469314]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Wu, Chao,Zheng, Yingjun,Li, Juanhua,et al. Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia[J]. FRONTIERS IN NEUROSCIENCE,2017.
APA	Wu, Chao.,Zheng, Yingjun.,Li, Juanhua.,Zhang, Bei.,Li, Ruikeng.,...&Li, Liang.(2017).Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia.FRONTIERS IN NEUROSCIENCE.
MLA	Wu, Chao,et al."Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia".FRONTIERS IN NEUROSCIENCE (2017).