Brain substrates underlying auditory speech priming in healthy listeners   and listeners with schizophrenia

doi:10.1017/S0033291716002816

CORC > 北京大学 > 生命科学学院

	Brain substrates underlying auditory speech priming in healthy listeners and listeners with schizophrenia
	Wu, C. ; Zheng, Y. ; Li, J. ; Wu, H. ; She, S. ; Liu, S. ; Ning, Y. ; Li, L.
刊名	PSYCHOLOGICAL MEDICINE
	2017
关键词	Auditory speech priming informational masking pars triangularis of the inferior frontal gyrus schizophrenia speech recognition. PERCEIVED SPATIAL SEPARATION INFERIOR FRONTAL GYRUS INFORMATIONAL MASKING FUNCTIONAL CONNECTIVITY LANGUAGE NETWORK OLDER-ADULTS SENTENCE COMPREHENSION AMBIGUITY-RESOLUTION RESPONSE-INHIBITION COMPETING SPEECH
DOI	10.1017/S0033291716002816
英文摘要	Background. Under 'cocktail party' listening conditions, healthy listeners and listeners with schizophrenia can use temporally pre-presented auditory speech-priming (ASP) stimuli to improve target-speech recognition, even though listeners with schizophrenia are more vulnerable to informational speech masking. Method. Using functional magnetic resonance imaging, this study searched for both brain substrates underlying the unmasking effect of ASP in 16 healthy controls and 22 patients with schizophrenia, and brain substrates underlying schizophrenia-related speech-recognition deficits under speech-masking conditions. Results. In both controls and patients, introducing the ASP condition (against the auditory non-speech-priming condition) not only activated the left superior temporal gyrus (STG) and left posterior middle temporal gyrus (pMTG), but also enhanced functional connectivity of the left STG/pMTG with the left caudate. It also enhanced functional connectivity of the left STG/pMTG with the left pars triangularis of the inferior frontal gyrus (TriIFG) in controls and that with the left Rolandic operculum in patients. The strength of functional connectivity between the left STG and left TriIFG was correlated with target-speech recognition under the speech-masking condition in both controls and patients, but reduced in patients. Conclusions. The left STG/pMTG and their ASP-related functional connectivity with both the left caudate and some frontal regions (the left TriIFG in healthy listeners and the left Rolandic operculum in listeners with schizophrenia) are involved in the unmasking effect of ASP, possibly through facilitating the following processes: masker-signal inhibition, target-speech encoding, and speech production. The schizophrenia-related reduction of functional connectivity between the left STG and left TriIFG augments the vulnerability of speech recognition to speech masking.; '973' National Basic Research Program of China [2015\|CB351800, 2011CB707805]; National High Technology Research and Development Program of China (863 Program) [2015AA016306]; National Natural Science Foundation of China [31170985]; Planned Science and Technology Projects of Guangzhou [2014Y2-00105]; Guangzhou Municipal Key Disciplines in Medicine for Guangzhou Brain Hospital [GBH2014-QN04, GBH2014-ZD06]; Chinese National Key Clinical Program in Psychiatry [201201004]; China Postdoctoral Science Foundation General Program [2013M530453]; SCI(E); SSCI; ARTICLE; 5; 837-852; 47
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469303]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Wu, C.,Zheng, Y.,Li, J.,et al. Brain substrates underlying auditory speech priming in healthy listeners and listeners with schizophrenia[J]. PSYCHOLOGICAL MEDICINE,2017.
APA	Wu, C..,Zheng, Y..,Li, J..,Wu, H..,She, S..,...&Li, L..(2017).Brain substrates underlying auditory speech priming in healthy listeners and listeners with schizophrenia.PSYCHOLOGICAL MEDICINE.
MLA	Wu, C.,et al."Brain substrates underlying auditory speech priming in healthy listeners and listeners with schizophrenia".PSYCHOLOGICAL MEDICINE (2017).