Perceptual Learning of Contrast Detection in the Human Lateral   Geniculate Nucleus

doi:10.1016/j.cub.2016.09.034

CORC > 北京大学 > 生命科学学院

	Perceptual Learning of Contrast Detection in the Human Lateral Geniculate Nucleus
	Yu, Qinlin ; Zhang, Peng ; Qiu, Jiang ; Fang, Fang
刊名	CURRENT BIOLOGY
	2016
关键词	PRIMARY VISUAL-CORTEX CORTICAL PLASTICITY OCULAR DOMINANCE TEXTURE-DISCRIMINATION MONOCULAR DEPRIVATION STRIATE CORTEX V1 NEURONS AREA V4 ORIENTATION RESPONSES
DOI	10.1016/j.cub.2016.09.034
英文摘要	The brain is continuously modified by perceptual experience throughout life. Perceptual learning, which refers to the long-term performance improvement resulting from practice, has been widely used as a paradigm to study experience-dependent brain plasticity in adults [1, 2]. In the visual system, adult plasticity is largely believed to be restricted to the cortex, with subcortical structures losing their capacity for change after a critical period of development [3, 4]. Although various cortical mechanisms have been shown to mediate visual perceptual learning [5-12], there has been no reported investigation of perceptual learning in subcortical nuclei. Here, human subjects were trained on a contrast detection task for 30 days, leading to a significant contrast sensitivity improvement that was specific to the trained eye and the trained visual hemifield. Training also resulted in an eye-and hemifield-specific fMRI signal increase to low-contrast patterns in the magnocellular layers of the lateral geniculate nucleus (LGN), even when subjects did not pay attention to the patterns. Such an increase was absent in the parvocellular layers of the LGN and visual cortical areas. Furthermore, the behavioral benefit significantly correlated with the neural enhancement. These findings suggest that LGN signals can be amplified by training to detect faint patterns. Neural plasticity induced by perceptual learning in human adults might not be confined to the cortical level but might occur as early as at the thalamic level.; NSFC [31230029, 31421003, 61621136008, 61527804]; MOST [2015CB351800]; SCI(E); ARTICLE; ffang@pku.edu.cn; 23; 3176-3182; 26
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/458112]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Yu, Qinlin,Zhang, Peng,Qiu, Jiang,et al. Perceptual Learning of Contrast Detection in the Human Lateral Geniculate Nucleus[J]. CURRENT BIOLOGY,2016.
APA	Yu, Qinlin,Zhang, Peng,Qiu, Jiang,&Fang, Fang.(2016).Perceptual Learning of Contrast Detection in the Human Lateral Geniculate Nucleus.CURRENT BIOLOGY.
MLA	Yu, Qinlin,et al."Perceptual Learning of Contrast Detection in the Human Lateral Geniculate Nucleus".CURRENT BIOLOGY (2016).