Understanding the Genetic Mechanisms of Cancer Drug Resistance Using   Genomic Approaches

doi:10.1016/j.tig.2015.11.003

CORC > 北京大学 > 生命科学学院

	Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches
	Hu, Xueda ; Zhang, Zemin
刊名	TRENDS IN GENETICS
	2016
关键词	CELL LUNG-CANCER BREAST-CANCER COLORECTAL-CANCER ACQUIRED-RESISTANCE OVARIAN-CANCER BRAF(V600E) INHIBITION CISPLATIN RESISTANCE TUMOR HETEROGENEITY FEEDBACK ACTIVATION PATHWAY ALTERATIONS
DOI	10.1016/j.tig.2015.11.003
英文摘要	A major obstacle in precision cancer medicine is the inevitable resistance to targeted therapies. Tremendous effort and progress has been made over the past few years to understand the biochemical and genetic mechanisms underlying drug resistance, with the goal to eventually overcome such daunting challenges. Diverse mechanisms, such as secondary mutations, oncogene bypass, and epigenetic alterations, can all lead to drug resistance, and the number of known involved genes is growing rapidly, thus providing many possibilities to overcome resistance. The finding of these mechanisms and genes invariably requires the application of genomic and functional genomic approaches to tumors or cancer models. In this review, we briefly highlight the major drug-resistance mechanisms known today, and then focus primarily on the technological approaches leading to the advancement of this field.; National Science Foundation of China [31530036, 81573022]; Peking University 985 Program; SCI(E); PubMed; REVIEW; zemin@pku.edu.cn; 2; 127-137; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435778]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hu, Xueda,Zhang, Zemin. Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches[J]. TRENDS IN GENETICS,2016.
APA	Hu, Xueda,&Zhang, Zemin.(2016).Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches.TRENDS IN GENETICS.
MLA	Hu, Xueda,et al."Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches".TRENDS IN GENETICS (2016).